90748-01-9

Basic information

• Product Name: 4-HYDROXYMETHYL-PIPERIDINE HCL
• Synonyms: 4-PIPECOLINOL HYDROCHLORIDE;4-PIPERIDINEMETHANOL HCL;4-HYDROXYMETHYL-PIPERIDINE HCL;4-HYDROXYMETHYLPIPERIDINE HYDROCHLORIDE;H-PIC(4)-OL HCL;HEXAHYDROISONICOTINOL HYDROCHLORIDE;H-ISONICOT(H6)-OL HCL;4-PIPERIDINEMETHANOL, HYDROCHLORIDE
• CAS NO: 90748-01-9
• Molecular Formula: C6H14ClNO
• Molecular Weight: 151.63
• Mol File: 90748-01-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 198.2 °C at 760 mmHg
• Flash Point: 92.3 °C
• Appearance: /
• Density: 0.951g/cm³
• CAS DataBase Reference: 4-HYDROXYMETHYL-PIPERIDINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYMETHYL-PIPERIDINE HCL(90748-01-9)
• EPA Substance Registry System: 4-HYDROXYMETHYL-PIPERIDINE HCL(90748-01-9)

Safety Data

• Hazardous Substances Data: 90748-01-9(Hazardous Substances Data)

Usage

General Description

4-Hydroxymethyl-piperidine HCl is a chemical compound that consists of a piperidine ring with a hydroxymethyl group attached to it, and is in its hydrochloride salt form. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals, as well as in the manufacturing of various specialty chemicals. 4-HYDROXYMETHYL-PIPERIDINE HCL is known for its reactivity as a nucleophile and as a base in organic reactions, and it is also used as a precursor for the synthesis of other piperidine derivatives. Additionally, 4-Hydroxymethyl-piperidine HCl has potential applications in medicinal chemistry and drug discovery due to its structural features and biological activities.

Upstream product

• 7440-44-0 pyrographite 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 498-94-2 isonipecotic acid 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 586-95-8 pyridine-4-methanol 

Downstream Products

• 846057-27-0 1-[4-(hydroxymethyl)piperidin-1-yl]ethan-1-one 

Relevant articles and documents

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1) receptor, to processes of preparation of such compounds,

NOVEL COMPOUNDS AS GPR119 AGONISTS

The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.

HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY

Pyridazinone compounds of Formula I: (I) wherein: R' is alkyl or Ar, optionally substituted with at least one alkyl, halo? gen, hydroxyl, alkoxy, haloalkoxy, acid, ester, amino, nitro, amide, or alkoxyhalo; 2 R is independently alkyi, alkynyl, ester, amino, amide, acid, aryl, heteroaryl, aminoalkyl, -C(=0)alkyl, -C(=0)aryl, -C(=0)heteroaryl, -C(=0)heterocycloalkyl, - C(=0)heterocycloalkylAr, -C(=0)(CH2)nhalo, -C(=0)(CH2)nheterocyclyl, or -SC^Ar, optionally substituted with at least one alkyi, alkylhalo, halogen, nitro, aryl, heteroaryl, or heteroaryl(CH2)nhalo; R 3 and R4 are independently hydrogen, alkyi, alkenyl, alkynyl, aryl, heteroaryl; Ar is an aryl, heteroaryl, cycloalkyl, heterocycloalkyl group; n is an integer from 0-10; or a radiolabeled derivative thereof. The compounds are useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.