907545-27-1

Basic information

• Product Name: Ethyl 2-chloro-5-Methyl-1,3-thiazole-4-carboxylate
• Synonyms: Ethyl 2-chloro-5-Methyl-1,3-thiazole-4-carboxylate;Ethyl 2-chloro-5-Methylthiazole-4-carboxylate;2-Chloro-5-Methyl-1,3-thiazole-4-carboxylic acid ethyl ester;2-Chloro-5-methylthiazole-4-carboxylic acid ethyl ester
• CAS NO: 907545-27-1
• Molecular Formula: C₇H₈ClNO₂S
• Molecular Weight: 205.66192
• Mol File: 907545-27-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 291.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.328±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -1.02±0.10(Predicted)
• CAS DataBase Reference: Ethyl 2-chloro-5-Methyl-1,3-thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-chloro-5-Methyl-1,3-thiazole-4-carboxylate(907545-27-1)
• EPA Substance Registry System: Ethyl 2-chloro-5-Methyl-1,3-thiazole-4-carboxylate(907545-27-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 907545-27-1(Hazardous Substances Data)

Usage

Description

Ethyl 2-chloro-5-methyl-1,3-thiazole-4-carboxylate is an organic compound that serves as a valuable reactant in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a thiazole ring and a carboxylate group, making it a versatile building block for the development of new drugs and therapeutic agents.

Uses

Used in Pharmaceutical Industry:
Ethyl 2-chloro-5-methyl-1,3-thiazole-4-carboxylate is used as a key reactant for the preparation of bicyclic octahydrocyclopenta-pyrrolo, which is an antagonist of retinol-binding protein 4 (RBP4). This antagonist has the potential to mitigate further neurodegeneration, making it a promising candidate for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.
In addition to its role in the synthesis of RBP4 antagonists, Ethyl 2-chloro-5-methyl-1,3-thiazole-4-carboxylate may also be utilized in the development of other therapeutic agents targeting different biological pathways and diseases. Its unique chemical structure allows for further functionalization and modification, enabling the creation of novel compounds with diverse pharmacological properties.

Upstream product

• 72054-60-5 2-amino-5-methylthiazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS

Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, and Q are defined herein.