90788-17-3

Basic information

• Product Name: Benzenepropanoic acid, a-[(dimethylamino)methyl]-, methyl ester
• CAS NO: 90788-17-3
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 90788-17-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-[(dimethylamino)methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-[(dimethylamino)methyl]-, methyl ester(90788-17-3)
• EPA Substance Registry System: Benzenepropanoic acid, a-[(dimethylamino)methyl]-, methyl ester(90788-17-3)

Safety Data

• Hazardous Substances Data: 90788-17-3(Hazardous Substances Data)

Upstream product

• 3070-71-1 methyl 2-benzylacrylate 
• 220438-32-4 (S)-(+)-methyl 2-<(trimethylsilyl)methyl>amino-3-phenylpropionate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 3853-06-3 methyl 3-(dimethylamino)propionate 
• 100-39-0 benzyl bromide 

Downstream Products

• 196395-19-4 (S)-2-((R)-2-Acetylsulfanylmethyl-3-phenyl-propionylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 182479-25-0 (S)-3-(1H-Indol-3-yl)-2-((S)-2-mercaptomethyl-3-phenyl-propionylamino)-propionic acid methyl ester 
• 182479-27-2 (S)-3-(1H-Indol-3-yl)-2-((R)-2-mercaptomethyl-3-phenyl-propionylamino)-propionic acid methyl ester 

Relevant articles and documents

Novel isomerization reaction of N,N-dimethyl-α-(methoxycarbonyl)-4- substituted-benzylammonium N-methylides

Fluoride ion-induced desilylation of N,N-dimethyl-N- [(trimethylsilyl)methyl]-α-(methoxycarbonyl)4-substituted benzylammonium salts (7) gave two Stevens rearrangement products: methyl 3-(dimethylamino)- 2-(4-substituted phenyl)propionates (13) from N-methylides 8, and methyl 3- (dimethylamino)-3-(4-substituted phenyl)propionates (15) from N-benzylides 10. Additional Stevens rearrangement products, methyl 2-(dimethylamino)-3- (4-substituted phenyl)propionates (16), were competitively formed from ylides 12 when the cesium fluoride used was not predried. The mechanism of the isomerization from methylides 8, which was initially generated, to 10 and 12 is discussed.

PROPYLAMINE DERIVATIVES

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