907997-07-3Relevant articles and documents
Complexes of 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone (propafenone) with copper(II): Crystal structure of the mononuclear Cu(II) complex with propafenone
Getova,Bontchev,Mehandjiev,Bontchev
, p. 2254 - 2260 (2006)
Two new copper(II) complexes with the antiarrythmic drug propafenone (HPr) have been synthesized: the mononuclear complex CuPr2 (1) and the binuclear one Cu2Pr2Cl2 (2) and have been studied using electronic, IR and EPR spectra, magnetochemical, thermogravimetric and single-crystal X-ray diffraction methods. In the mononuclear complex 1, copper(II) is coordinated bidentately with the NH and deprotonated OH groups of two drug molecules forming a nearly square-planar structure of the type CuL2, with a CuN2O2 chromophore. In complex 2 each copper atom is coordinated with one N atom from one ligand, one terminal chlorine atom and two oxygen atoms from two different ligand molecules which serve as bridges in the formation of the binuclear complex 2. Measurable antiferromagnetic interactions between the two paramagnetic Cu(II) centers are responsible for some interesting magnetic properties.
