908129-33-9

Basic information

• Product Name: (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide
• Synonyms: (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide
• CAS NO: 908129-33-9
• Molecular Weight: 345.357
• Mol File: 908129-33-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide(908129-33-9)
• EPA Substance Registry System: (S)-2-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)propanamide(908129-33-9)

Safety Data

• Hazardous Substances Data: 908129-33-9(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 

Downstream Products

• 1380433-24-8 methyl (S)-3,3-di(3,4-dimethylphenyl)-2-phthalimidopropionate 
• 1380433-18-0 (S)-N-(3,3-di(3,4-dimethylphenyl)-2-phthalimidopropionyl)-8-aminoquinoline 
• 1380433-19-1 (S)-N-(3,3-di(3,4-dimethylphenyl)-2-phthalimidopropionyl)-8-aminoquinoline 

Relevant articles and documents

Palladium-catalyzed stereoretentive olefination of unactivated C(sp3)-H bonds with vinyl iodides at room temperature: Synthesis of β-vinyl α-amino acids

A method is reported for palladium-catalyzed N-quinolyl carboxamide-directed olefination of the unactivated C(sp3)-H bonds of phthaloyl alanine with a broad range of vinyl iodides at room temperature. This reaction represents the first example of the stereoretentive installation of multisubstituted terminal and internal olefins onto unactivated C(sp3)-H bonds. These methods enable access to a wide range of challenging β-vinyl α-amino acid products in a streamlined and controllable fashion, beginning from simple precursors.

Palladium-catalyzed direct intermolecular silylation of remote unactivated C(sp3)-H bonds

An efficient and convenient method has been developed to achieve direct silylation of unactivated remote primary or secondary C(sp3)-H bonds to form C-Si bonds with hexamethyldisilane (HMDS). This method highlights the emerging strategy to transform unactivated methyl or methylene into versatile functional groups in organic synthesis and provides a new method to construct functionalized C-Si bonds for synthetic chemistry.

Nonnatural amino acid synthesis by using carbon-hydrogen bond functionalization methodology

Taking direction well: Substituted phenylalanine derivatives were prepared by C-H bond functionalization (see scheme). The syntheses are highly convergent and employ an N-phthaloylalanine with a 2-thiomethylaniline directing group. The use of an 8-aminoquinoline directing group allows for the diarylation of methyl and the diastereoselective arylation of methylene groups. Copyright