908303-26-4 Usage
Description
Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)is a complex organic compound with a unique molecular structure that features a pyrrolidine core and a chiral center at the 2-position. Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)is characterized by the presence of trifluoromethyl and trimethylsilyl groups, which contribute to its unique chemical properties and potential applications in various fields.
Uses
Used in Catalyst Applications:
Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)is used as a catalyst in various organic reactions, including:
1. Cyclocondensation of enals with methylenepyrrolidines: This reaction involves the formation of cyclic compounds through the condensation of enals and methylenepyrrolidines, facilitated by the chiral catalyst.
2. Organocatalytic additions of β-ketosulfoxides to conjugated aldehydes: The chiral catalyst promotes the addition of β-ketosulfoxides to conjugated aldehydes, leading to the formation of new chiral centers and valuable synthetic intermediates.
3. Organocatalytic aza-Michael reactions: The catalyst is employed in aza-Michael reactions, which are important for the synthesis of nitrogen-containing compounds and natural products.
4. Stereoselective propargylic alkylation of propargylic esters with aldehydes: The chiral catalyst enables the selective alkylation of propargylic esters with aldehydes, providing access to enantiomerically pure products.
5. Epoxidation or aziridination of α,β-unsaturated aldehydes: The catalyst is used in the epoxidation or aziridination of α,β-unsaturated aldehydes, which are key steps in the synthesis of various biologically active compounds.
6. Feist-Benary reactions of 1,3-dicarbonyls: The chiral catalyst is employed in the Feist-Benary reaction, which is a useful method for the synthesis of complex organic molecules with multiple stereocenters.
Used in Pharmaceutical Industry:
Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)is used as a chiral catalyst for the synthesis of enantiomerically pure pharmaceutical compounds, enabling the production of single enantiomers with desired biological activities and reduced side effects.
Used in Fine Chemicals Industry:
The chiral catalyst is used in the synthesis of fine chemicals, such as fragrances, flavors, and agrochemicals, where enantioselectivity and stereochemistry play a crucial role in determining the properties and efficacy of the final products.
Check Digit Verification of cas no
The CAS Registry Mumber 908303-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,3,0 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 908303-26:
(8*9)+(7*0)+(6*8)+(5*3)+(4*0)+(3*3)+(2*2)+(1*6)=154
154 % 10 = 4
So 908303-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H23F12NOSi/c1-39(2,3)38-20(19-5-4-6-37-19,13-7-15(21(25,26)27)11-16(8-13)22(28,29)30)14-9-17(23(31,32)33)12-18(10-14)24(34,35)36/h7-12,19,37H,4-6H2,1-3H3/t19-/m1/s1
908303-26-4Relevant articles and documents
PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
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Page/Page column 67-68, (2010/08/07)
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
