908355-84-0 Usage
General Description
7-chlorothiazolo[4,5-c]pyridine-2-thiol is a chemical compound with a relatively complex molecular structure. While specific information about this specific chemical's properties, uses, or hazards is sparse, it can be inferred from its structural components that it belongs to the categories of organic compounds known as thiazolopyridines - compounds containing a thiazole ring fused to a pyridine ring. Chemicals in these categories tend to be used in various industrial processes, often as intermediate components in the production of larger, more complex compounds. However, thiol compounds are generally known to have a strong, unpleasant smell. As with all chemicals, handling 7-chlorothiazolo[4,5-c]pyridine-2-thiol would require appropriate safety procedures to prevent potential health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 908355-84-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,3,5 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 908355-84:
(8*9)+(7*0)+(6*8)+(5*3)+(4*5)+(3*5)+(2*8)+(1*4)=190
190 % 10 = 0
So 908355-84-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClN2S2/c7-3-1-8-2-4-5(3)11-6(10)9-4/h1-2H,(H,9,10)
908355-84-0Relevant articles and documents
7′-Substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors
Zhang, Lin,Fan, Junhua,Vu, Khang,Hong, Kevin,Le Brazidec, Jean-Yves,Shi, Jiandong,Biamonte, Marco,Busch, David J.,Lough, Rachel E.,Grecko, Roy,Ran, Yingqing,Sensintaffar, John L.,Kamal, Adeela,Lundgren, Karen,Burrows, Francis J.,Mansfield, Robert,Timony, Gregg A.,Ulm, Edgar H.,Kasibhatla, Srinivas R.,Boehm, Marcus F.
, p. 5352 - 5362 (2007/10/03)
We report on the discovery of benzo- and pyridinothiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally sensitive to substitutions on the aromatic ring with a 7′-substituent essential for activity. Some of these compounds exhibit low nanomolar inhibition activity in a Her-2 degradation assay (28-150 nM), good aqueous solubility, and oral bioavailability profiles in mice. In vivo efficacy experiments demonstrate that compounds of this class inhibit tumor growth in an N87 human colon cancer xenograft model via oral administration as shown with compound 37 (8-(7-chloro-benzothiazol-2-ylsulfanyl)-9-(2-cyclopropylamino-ethyl) -9H-purin-6-ylamine).
