90906-40-4 Usage
Description
(+/-)4-HDOHE, also known as 4-hydroxy-2 docosahexaenoic acid, is an autoxidation product of docosahexaenoic acid (DHA) that can be produced in vitro and in biological systems such as rat liver, brain, and intestinal microsomes. It is also generated through enzymatic transformation of DHA by RBL-1 cells, with the S-isomer being the most likely enzymatic product. (+/-)4-HDOHE serves as a potential marker of oxidative stress in the brain and retina, where DHA is a prevalent polyunsaturated fatty acid.
Uses
Used in Neurological Applications:
(+/-)4-HDOHE is used as a biomarker for oxidative stress in the brain, helping to identify and monitor the presence of oxidative stress in neurological conditions and diseases.
Used in Ophthalmological Applications:
(+/-)4-HDOHE is used as a biomarker for oxidative stress in the retina, assisting in the detection and assessment of oxidative stress-related eye conditions and potential retinal damage.
Used in Research and Diagnostics:
(+/-)4-HDOHE is utilized in scientific research to study the role of oxidative stress in various physiological and pathological processes, as well as in the development of diagnostic tools and methods for assessing oxidative stress levels in biological samples.
Check Digit Verification of cas no
The CAS Registry Mumber 90906-40-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,9,0 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 90906-40:
(7*9)+(6*0)+(5*9)+(4*0)+(3*6)+(2*4)+(1*0)=134
134 % 10 = 4
So 90906-40-4 is a valid CAS Registry Number.
90906-40-4Relevant articles and documents
SYNTHESIS OF RESOLVINS AND INTERMEDIATES, COMPOUNDS PREPARED THEREBY, AND USES THEREOF
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Page/Page column 52, (2008/12/04)
Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key int
Synthesis of docosahexaenoic acid derivatives designed as novel PPARγ agonists and antidiabetic agents
Itoh, Toshimasa,Murota, Itsuki,Yoshikai, Kazuyoshi,Yamada, Sachiko,Yamamoto, Keiko
, p. 98 - 108 (2007/10/03)
To discover novel peroxisome proliferator-activated receptor γ (PPARγ) agonists that could be used as antidiabetic agents, we designed docosahexaenoic acid (DHA) derivatives (2 and 3), which have a hydrophilic substituent at the C(4)-position, based on the crystal structure of the ligand-binding pocket of PPARγ. These compounds were synthesized via iodolactone as a key intermediate. We found that both DHA derivatives (2 and 3) showed PPARγ transactivation higher than, or comparable to, that of pioglitazone, which is a TZD derivative used as an antidiabetic agent. DHA derivatives related to these potent compounds 2 and 3 were also synthesized to study structure-activity relationships. Furthermore, 4-OH DHA 2, which shows strong PPARγ transcriptional activity, was separated as an optically pure form.
Synthesis of polyconjugated fatty acids
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Page 3; 12, (2010/02/10)
The present invention relates to fatty acids. In particular, the present invention provides polyconjugated fatty acids, and methods of their synthesis and their use.