909412-59-5Relevant articles and documents
Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K+ Buffer
Street, Steven T. G.,Chin, Donovan N.,Hollingworth, Gregory J.,Berry, Monica,Morales, Juan C.,Galan, M. Carmen
, p. 6953 - 6958 (2017)
Selective G-quadruplex ligands offer great promise for the development of anti-cancer therapies. A novel series of divalent cationic naphthalene diimide ligands that selectively bind to the hybrid form of the human telomeric G-quadruplex in K+ buffer are described herein. We demonstrate that an imidazolium-bearing mannoside-conjugate is the most selective ligand to date for this quadruplex against several other quadruplex and duplex structures. We also show that a similarly selective methylpiperazine-bearing ligand was more toxic to HeLa cancer cells than doxorubicin, whilst exhibiting three times less toxicity towards fetal lung fibroblasts WI-38.
Reversible fabrication and self-assembly of a gemini supra-amphiphile driven by dynamic covalent bonds
Shi, Lijuan,Liu, Fenglin,Liu, Tingting,Chen, Jingsi,Xu, Shaobo,Zeng, Hongbo
, p. 5995 - 6000 (2018)
A smart gemini supra-amphiphile behaving with pH/CO2 dual-sensitive hierarchical self-assembly was fabricated under the effect of dynamic covalent bonds. In the presence of an amino-functionalized cation, water-insoluble terephthalaldehyde, and an amphiphilic anion, the benzoic imine bond can initiate the transformation from a single-tailed supra-amphiphile to a gemini supra-amphiphile with increasing pH, followed by the subsequent evolution from micelles to vesicles. Reversible self-assembly and disassembly of the gemini supra-amphiphile can be realized via CO2/N2 treatment, thus inducing the fission and reversion of vesicles. Interestingly, the flexible nature of supra-amphiphiles allows for the hierarchical assembly of vesicles, leading to the formation of aqueous two-phase systems. Multiple responsive supra-amphiphiles have useful applications in the fabrication of smart supra-molecular materials, including self-healing materials, nanocarriers and chemosensors.
Exploration of amino-functionalized ionic liquids as ligand and base for heck reaction
Liu, Jie,Liu, Hongqiang,Wang, Lei
experimental part, p. 386 - 391 (2010/07/05)
A kind of amino-functionalized ionic liquid has been prepared and investigated as ligand and base for the Heck reactions between aryl iodides and bromides with olefins in the presence of a catalytic amount of Pd submicron powder in [Bmim]PF6. The reaction
