90971-76-9

Basic information

• Product Name: 1H-Pyrrole-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]-
• CAS NO: 90971-76-9
• Molecular Formula: C14H25NOSi
• Molecular Weight: 251.444
• Mol File: 90971-76-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]-(90971-76-9)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]-(90971-76-9)

Safety Data

• Hazardous Substances Data: 90971-76-9(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-3-carboxaldehyde, 1-[tris(1-methylethyl)silyl]- is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a derivative of pyrrole, a heterocyclic aromatic compound, with a carboxaldehyde functional group attached at the 3-position. The addition of the tris(1-methylethyl)silyl group enhances the stability and reactivity of the compound, making it valuable for various chemical reactions. This chemical has applications in the production of pharmaceuticals, agrochemicals, and other organic compounds, and its unique structure makes it an important building block for the synthesis of diverse molecules.

Upstream product

• 79-37-8 oxalyl dichloride 
• 87630-35-1 N-triisopropylsilylpyrrole 
• 13154-24-0 triisopropylsilyl chloride 
• 87630-36-2 3-bromo-1-triisopropylsilanyl-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 93362-46-0 3-lithio-1-(triisopropylsilyl)pyrrole 

Downstream Products

• 7126-39-8 pyrrole-3-carboxaldehyde 

Relevant articles and documents

Platinum-catalyzed domino reaction with benziodoxole reagents for accessing benzene-alkynylated Indoles

Indoles are omnipresent in natural products, bioactive molecules, and organic materials. Consequently, their synthesis or functionalization are important fields of research in organic chemistry. Most works focus on installation or modification of the pyrrole ring. To access benzene-ring-functionalized indoles with an unsubstituted pyrrole ring remains more challenging. Reported herein is a platinum-catalyzed cyclization/alkynylation domino process to selectively obtain C5- or C6-functionalized indoles starting from easily available pyrroles. The work combines, for the first time, a platinum catalyst with ethynylbenziodoxole hypervalent iodine reagents in a domino process for the synthesis of polyfunctionalized arene rings and gives access to important building blocks for the synthesis of bioactive compounds and organic materials.

Inhibitors of bacterial biofilms and related methods

Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.

Synthesis of New 3-Substituted Pyrroles

The synthesis of 3-alkyl- (4), 3-(ω-bromoalkyl)- (5), 3-iodo- (6), 3-formyl- (9a), 3-acetyl-1-(triisopropylsilyl)pyrrole (9b), of 2--2-propanol (7), 1-(triisopropylsilyl)-3-pyrrolecarboxylic acid (8), and 7-heptanoic acid (10) as well as the desilylation of these products to the corresponding 3-substituted pyrroles 11 is described.Intermediates in these syntheses are 1-(triisopropylsilyl)pyrrole (1), 3-bromo- (2), and 3-lithio-1-(triisopropylsilyl)pyrrole (3). - Keywords: Pyrroles, substituted in position 3 / 1-(Triisopropylsilyl)pyrroles, substituted in position 3