Cas 90981-26-3,5-chloro-N'-hydroxythiophene-2-carboximidamide

90981-26-3

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Basic information

Product Name: 5-chloro-N'-hydroxythiophene-2-carboximidamide
Synonyms: 5-chloro-N'-hydroxythiophene-2-carboximidamide
CAS NO:90981-26-3
Molecular Formula:
Molecular Weight: 176.626
EINECS: N/A
Product Categories: N/A
Mol File: 90981-26-3.mol
Article Data: 1

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 5-chloro-N'-hydroxythiophene-2-carboximidamide(CAS DataBase Reference)
NIST Chemistry Reference: 5-chloro-N'-hydroxythiophene-2-carboximidamide(90981-26-3)
EPA Substance Registry System: 5-chloro-N'-hydroxythiophene-2-carboximidamide(90981-26-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 90981-26-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 90981-26-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,9,8 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 90981-26:
(7*9)+(6*0)+(5*9)+(4*8)+(3*1)+(2*2)+(1*6)=153
153 % 10 = 3
So 90981-26-3 is a valid CAS Registry Number.

90981-26-3Upstream product

50478-16-5 5-chlorothiophene-2-carbonitrile

90981-26-3Downstream Products

90981-26-3Relevant articles and documents

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design

Yeh, Teng-Kuang,Song, Jen-Shin,Chang, Po-Wei,Yu, Jin-Chen,Chang, Chia-Hwa,Liao, Fang-Yu,Tien, Ya-Wen,Kuppusamy, Ramajayam,Li, An-Siou,Chen, Chi-Han,Chen, Chieh-Wen,Lin, Li-Mei,Chang, Hsin-Huei,Huang, Chih-Hsiang,Yao, Jau-Ying,Wu, Mine-Hsine,Peng, Yi-Hui,Hsueh, Ching-Cheng,Hsiao, Wen-Chi,Chen, Pei-Husan,Lin, Chin-Yu,Hsieh, Su-Huei,Shih, Chuan,Hung, Ming-Shiu,Wu, Su-Ying,Kuo, Ching-Chuan,Ueng, Shau-Hua

, (2021/12/20)

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular activity and pharmacokinetic (PK) properties of the compounds synthesized, including extension of the side chain of the N-hydroxythiophene-2-carboximidamide core, resulted in compound 27a, a potent IDO1 inhibitor which demonstrated significant (51%) in vivo target inhibition on IDO1 in a human SK-OV-3 ovarian xenograft tumor mouse model. This strategy is expected to be applicable to the discovery of additional IDO1 inhibitors for the treatment of other diseases susceptible to modulation of IDO1.

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