909863-34-9

Basic information

• Product Name: 4-[(5-chloro-2-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propyloxy]-7-methoxyquinazoline
• Synonyms: 4-[(5-chloro-2-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propyloxy]-7-methoxyquinazoline
• CAS NO: 909863-34-9
• Molecular Weight: 446.909
• Mol File: 909863-34-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(5-chloro-2-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propyloxy]-7-methoxyquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(5-chloro-2-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propyloxy]-7-methoxyquinazoline(909863-34-9)
• EPA Substance Registry System: 4-[(5-chloro-2-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propyloxy]-7-methoxyquinazoline(909863-34-9)

Safety Data

• Hazardous Substances Data: 909863-34-9(Hazardous Substances Data)

Upstream product

• 2106-05-0 5-chloro-2-fluoroaniline 
• 199327-59-8 4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline 

Relevant articles and documents

Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors

We demonstrate that the acrylamide group can be used to improve the drug-like properties of potential drug candidates. In the EGFR inhibitor development, both the solubility and membrane permeability properties of compounds 6a and 7, each containing an acrylamide group, were substantially better than those of gefitinib (1) and AZD3759 (2), respectively. We demonstrated that incorporation of an acrylamide moiety could serve as a good strategy for improving drug-like properties.