910297-51-7

Basic information

• Product Name: N-Deshydroxyethyl Dasatinib
• Synonyms: N-(2-Chloro-6-methylphenyl)-2-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolecarboxamide;N-Deshydroxyethyl Dasatinib;Dasatinib metabolite M4;Dasatinib Impurity A
• CAS NO: 910297-51-7
• Molecular Formula: C₂₀H₂₂ClN₇OS
• Molecular Weight: 443.95
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 910297-51-7.mol
• Article Data: 20

Chemical Properties

• Melting Point: >300°C
• Appearance: /
• Density: 1.404g/cm³
• Refractive Index: 1.69
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 10.94±0.70(Predicted)
• CAS DataBase Reference: N-Deshydroxyethyl Dasatinib(CAS DataBase Reference)
• NIST Chemistry Reference: N-Deshydroxyethyl Dasatinib(910297-51-7)
• EPA Substance Registry System: N-Deshydroxyethyl Dasatinib(910297-51-7)

Safety Data

• Hazardous Substances Data: 910297-51-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 910297-51-7 differently. You can refer to the following data:
1. N-Deshydroxyethyl Dasatinib is a metabolite of Dasatinib, Used in the treatment of cancers and immune diseases.
2. A metabolite of Dasatinib. Used in the treatment of cancers and immune diseases. It is a COVID19-related research product.

InChI:InChI=1/C20H22ClN7OS/c1-12-4-3-5-14(21)18(12)27-19(29)15-11-23-20(30-15)26-16-10-17(25-13(2)24-16)28-8-6-22-7-9-28/h3-5,10-11,22H,6-9H2,1-2H3,(H,27,29)(H,23,24,25,26)

Upstream product

• 110-85-0 piperazine 
• 302964-08-5 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 
• 302964-06-3 [5-(2-chloro-6-methylphenylcarbamoyl)thiazol-2-yl]-carbamic acid tert-butyl ester 
• 87-63-8 2-chloro-6-methylaniline 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 1780-26-3 2,4-dichloro-2-methylpyrimidine 
• 302964-24-5 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide 

Downstream Products

• 910297-62-0 ethyl 2-(4-(6-(5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-ylamino)-2-methylpyrimidin-4-yl)piperazin-1-yl)acetate 

Relevant articles and documents

Compound capable of degrading Bcr-Abl or PARP as well as preparation method and pharmaceutical application thereof

The invention relates to a compound shown in a general formula (Ia), (Ib), (Ic), (Id), (Ie), (If) or (Ig) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a co-crystal of the compound, an intermediate and a preparation method of the compound, and application of the compound in Bcr-Abl or PARP related diseases such as tumors. The chemical formula is B-K(Ia)B-Cy1-K(Ib)B-Cy1-Cy2-K(Ic)B-Cy1-Cy2-Cy3-K(Id)B-Cy1-Cy2-Cy3-Cy4-K(Ie).

PROTEIN DEGRADATION TARGETING COMPOUND, ANTI-TUMOR APPLICATION, INTERMEDIATE THEREOF AND USE OF INTERMEDIATE

The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE

Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.