910539-80-9Relevant articles and documents
Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold
Ekegren, Jenny K.,Gising, Johan,Wallberg, Hans,Larhed, Mats,Samuelsson, Bertil,Hallberg, Anders
, p. 3040 - 3043 (2008/02/12)
The development of synthetic protocol leading to HIV-1 protease inhibitors with a tertiary alcohol based transition-state mimicking unit and different P2 side chains was investigated. (2S)-2-benztloxirane-2-carboxylic acid ((S)-5) was used as a key interm