910918-83-1Relevant articles and documents
Synthesis and biological activity of novel 1-(2,3,4-trimethoxyphenyl)-2- {[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]thio}ethanone oxime ester derivatives
Xue, Wei,Song, Baoan,He, Wei,Wang, Hua,Yang, Song,Jin, Linhong,Hu, Deyu,Liu, Gang,Lu, Ping
, p. 867 - 871 (2007/10/03)
In a search for new fungicide and anticancer agent with improved biological properties and different bioactivity spectrum, we designed and synthesized a series of novel oxime esters containing 1,3,4-thiadiazole group in moderate yield starting from gallic acid. The title compounds were identified by IR, 1H NMR, 13C NMR and elemental analysis. The bioassay tests showed that these title compounds exhibit weak to moderate anticancer activity in vitro by MTT method.