911048-26-5

Basic information

• Product Name: (3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophene-1-carbonitrile
• Synonyms: (3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophene-1-carbonitrile
• CAS NO: 911048-26-5
• Molecular Weight: 203.308
• Mol File: 911048-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophene-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophene-1-carbonitrile(911048-26-5)
• EPA Substance Registry System: (3bS,4aR)-3,4,4-trimethyl-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]thiophene-1-carbonitrile(911048-26-5)

Safety Data

• Hazardous Substances Data: 911048-26-5(Hazardous Substances Data)

Upstream product

• 59463-56-8 thioacetic acid S-cyanomethyl ester 
• 340165-15-3 (1S,5R)-2-(1-chloro-(E)-ethylidene)-6,6-dimethylbicyclo[3.1.0]hexan-3-one 

Relevant articles and documents

Novel S1P1 receptor agonists - Part 1: From pyrazoles to thiophenes

From a high-throughput screening campaign aiming at the identification of novel S1P1 receptor agonists, the pyrazole derivative 2 emerged as a hit structure. Medicinal chemistry efforts focused not only on improving the potency of the compound but in particular also on resolving its inherent instability issue. This led to the discovery of novel bicyclo[3.1.0]hexane fused thiophene derivatives. Compounds with high affinity and selectivity for S1P1 efficiently reducing the blood lymphocyte count in the rat were identified. For instance, compound 85 showed EC50 values of 7 and 2880 nM on S1P1 and S1P3, respectively, had favorable pharmacokinetic properties in rat and dog, distributed well into brain tissue, and efficiently and dose dependently reduced the blood lymphocyte count in the rat. After oral administration to spontaneously hypertensive rats, the S1P 1 selective compound 85 showed no effect on mean arterial blood pressure and affected the heart rate during the wake phase of the animals only.

NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS

The invention relates to novel thiophene derivatives of formula (l),their preparation and their use as pharmaceutically active compounds. Said compounds particulary act as immunosuppressive agents. wherein ring A represents oxadiazole and the other substituents are as defined in the description.