911066-02-9Relevant articles and documents
Novel pyrimidine derivatives for drug design
Zaky,Mohamed,Kandil
, p. 283 - 292 (2007/10/03)
TRIMETHOPRIM [2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine] (1 a) reacted with benzaldehyde and acetic anhydride to afford 2,4-disubstituted amino derivatives (1b-c). The methylene group of compounds (1a-c) was oxidized by convenient and simple method using sodium dichromate and acetic acid to give the corresponding ketonic derivatives (2a-c). (2a) was converted to the corresponding thio derivative using phosphrous pentasulphide or Lawsson's reagent which is the target of our work. The reaction of ketonic derivatives (2a-c) with different nitrogen nucleophiles have been also reported.