911837-69-9Relevant articles and documents
Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-taxol conformation
Tang, Shoubin,Yang, Chao,Brodie, Peggy,Bane, Susan,Ravindra, Rudravajhala,Sharma, Shubhada,Jiang, Yi,Snyder, James P.,Kingston, David G. I.
, p. 3983 - 3986 (2006)
The synthesis of the bridged A-nor-paclitaxel 4 has been achieved from paclitaxel in a key test of the T-Taxol conformational hypothesis. Although the unbridged A-nor-paclitaxel 3 is essentially noncytotoxic, the bridged analogue 4 is strongly cytotoxic.
