91192-32-4

Basic information

• Product Name: 2-HYDROXY-6-METHOXYQUINOXALINE
• Synonyms: 2-HYDROXY-6-METHOXYQUINOXALINE;6-Methoxyquinoxalin-2-ol;2-Hydroxy-6-Methoxyq;6-Methoxyquinoxalin-2(1H)-one
• CAS NO: 91192-32-4
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 91192-32-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.32 g/cm³
• Refractive Index: 1.627
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-HYDROXY-6-METHOXYQUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-METHOXYQUINOXALINE(91192-32-4)
• EPA Substance Registry System: 2-HYDROXY-6-METHOXYQUINOXALINE(91192-32-4)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 91192-32-4(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-6-METHOXYQUINOXALINE is a chemical compound with the molecular formula C9H7NO3. It is a derivative of quinoxaline and contains a hydroxyl group and a methoxy group. 2-HYDROXY-6-METHOXYQUINOXALINE is used in organic synthesis and pharmaceutical research due to its potential pharmacological properties, including its antiviral, antimicrobial, and anticancer activities. It is also used as a building block in the production of various pharmaceuticals and agrochemicals. The compound's structure and properties make it a valuable tool for the development of new drugs and compounds with potential therapeutic applications.

InChI:InChI=1/C9H8N2O2/c1-13-6-2-3-7-8(4-6)10-5-9(12)11-7/h2-5H,1H3,(H,11,12)

Upstream product

• 298-12-4 Glyoxilic acid 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 39266-92-7 6-methoxyquinoxaline 1,4-dioxide 
• 924-44-7 glyoxylic acid ethyl ester 
• 4685-47-6 3,4-dimethylanisole 
• 111697-39-3 1-acetoxy-6-methoxy-2(1H)-quinoxalinone 
• 111697-40-6 1-hydroxy-6-methoxy-2(1H)-quinoxalinone 
• 90417-61-1 6-Methoxy-4-oxy-1H-quinoxalin-2-one 
• 64376-06-3 acetoacetic acid-(4-methoxy-2-nitro-anilide) 

Downstream Products

• 1315336-99-2 6-methoxy-2-(perfluorophenyl)quinoxaline 
• 1315336-89-0 6-methoxyquinoxalin-2-yl 4-methylbenzenesulfonate 
• 55687-11-1 6-methoxy-2-chloroquinoxaline 
• 55686-93-6 2-chloro-7-methoxyquinoxaline 
• 39267-04-4 2,3-dichloro-6-methoxyquinoxaline 

Relevant articles and documents

Electro-oxidative C-H alkylation of quinoxalin-2(1: H)-ones with organoboron compounds

Radical cleavage of C-B bonds to accomplish C-H functionalization is synthetically appealing but practically challenging. We report herein a mild electro-oxidative method for efficient C-H alkylation of quinoxalin-2(1H)-ones by means of radical addition reactions of alkyl boronic acids and esters and alkyl trifluoroborates to afford C-C coupled products. This journal is

Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis

Herein, a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated. A wide range of functional groups are compatible, affording the corresponding products in moderate-to-good yields. Control experiments illustrate that the in situ generated 1O2 plays a central role in this reaction. This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure.

Construction of C(sp2)?C(sp3) Bond between Quinoxalin-2(1H)-ones and N-Hydroxyphthalimide Esters via Photocatalytic Decarboxylative Coupling

A novel visible-light-driven decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with quinoxalin-2(1H)-ones has been developed. This C(sp2)?C(sp3) bond-forming transformation exhibits excellent substrate generality with respect to both the coupling partners. Of note, a series of 3-primary alkyl-substituted quinoxalin-2(1H)-ones that were difficult to synthesize by previous methods could be obtained in moderate to excellent yields. Additionally, the mild conditions, easy availability of substrates, wide functional group tolerance and operational simplicity make this protocol practical in the synthesis of 3-alkylated quinoxalin-2(1H)-ones.