91262-95-2

Basic information

• Product Name: EXOTOXIN A
• Synonyms: EXOTOXIN A;EXOTOXIN A, PSEUDOMONAS AERUGINOSA;PSEUDOMONAS EXOTOXIN A;PSEUDOMONAS EXOTOXIN A FROM PSEUDOMONAS AERUGINOSA;Toxin A, exo- (Pseudomonas aeruginosa reduced)
• CAS NO: 91262-95-2
• Molecular Weight: 0
• Product Categories: Bacteria;Cell Signaling and Neuroscience;Toxins and Venoms
• Mol File: 91262-95-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: EXOTOXIN A(CAS DataBase Reference)
• NIST Chemistry Reference: EXOTOXIN A(91262-95-2)
• EPA Substance Registry System: EXOTOXIN A(91262-95-2)

Safety Data

• Hazard Codes: T,T+
• Statements: 23/24/25-26/27/28
• Safety Statements: 45-36/37-28
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: LF2991000
• Hazardous Substances Data: 91262-95-2(Hazardous Substances Data)

Usage

Description

Exotoxin A, secreted by Pseudomonas aeruginosa, is a member of the family mono-ADP-ribosyltransferases. It functions as a protein synthesis inhibitor by regulating the expression level of Bak, a pro-apoptotic protein.

Uses

Used in Pharmaceutical Industry:
Exotoxin A is used as a research tool for studying the mechanisms of protein synthesis inhibition and apoptosis regulation. Its ability to target and regulate Bak expression levels makes it a valuable asset in understanding the complex processes of cell death and survival.
Used in Biodefense Research:
Due to its potent biological activity, Exotoxin A is also utilized in biodefense research to develop countermeasures against potential threats involving Pseudomonas aeruginosa and other similar bacterial toxins. This research helps in the advancement of medical countermeasures and the improvement of public health safety.

Biochem/physiol Actions

Pseudomonas exotoxin A functions as an anticancer agent.It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.