91271-65-7

Basic information

• Product Name: [4-(MORPHOLINOMETHYL)PHENYL]METHANOL
• Synonyms: BUTTPARK 98\57-93;[4-(MORPHOLINOMETHYL)PHENYL]METHANOL;[4-(MORPHOLINOMETHYL)PHENYL]METHANOL(WXC08582)
• CAS NO: 91271-65-7
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 91271-65-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 94℃
• Boiling Point: 337.3°Cat760mmHg
• Flash Point: 157.8°C
• Appearance: /
• Density: 1.147g/cm³
• Vapor Pressure: 4.13E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: 14.43±0.10(Predicted)
• CAS DataBase Reference: [4-(MORPHOLINOMETHYL)PHENYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(MORPHOLINOMETHYL)PHENYL]METHANOL(91271-65-7)
• EPA Substance Registry System: [4-(MORPHOLINOMETHYL)PHENYL]METHANOL(91271-65-7)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 91271-65-7(Hazardous Substances Data)

Usage

General Description

[4-(Morpholinomethyl)phenyl]methanol is a chemical compound consisting of a phenyl ring with a morpholinomethyl group attached to it. It is classified as an alcohol due to the presence of a hydroxyl group, and it also contains a cyclic amine group in the form of a morpholine ring. [4-(MORPHOLINOMETHYL)PHENYL]METHANOL is often used in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity and functional groups. It can also act as a building block for the creation of more complex chemical structures, and its unique combination of aromatic and heterocyclic groups makes it a valuable tool in organic chemistry.

InChI:InChI=1/C12H17NO2/c14-10-12-3-1-11(2-4-12)9-13-5-7-15-8-6-13/h1-4,14H,5-10H2

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 26496-94-6 Ethyl 4-(bromomethyl)benzoate 
• 68453-56-5 methyl 4-(morpholinomethyl)benzoate 

Downstream Products

• 918904-44-6 {2-chloro-4-[3-(4-chloro-phenylethynyl)-5-(4-morpholin-4-ylmethyl-benzyIoxy)-phenylsulfanyl]-phenoxy}-acetic acid ethyl ester 
• 82413-63-6 4-(morpholin-4-ylmethyl)benzaldehyde 
• 1093190-73-8 4-(4-morpholin-4-ylmethylbenzylsulfanyl)benzoic acid methyl ester 
• 1323402-36-3 3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione 
• 1323407-21-1 4-carbamoyl-4-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-butyric acid methyl ester 
• 497843-73-9 4-[[4-(chloromethyl)phenyl]methyl]morpholine 
• 1093190-77-2 N-((1S,2R)-2-hydroxy-1-hydroxycarbamoylpropyl)-4-(4-morpholin-4-ylmethylbenzylsulfanyl)benzamide trifluoroacetate 
• 1093190-74-9 4-(4-morpholin-4-ylmethylbenzylsulfanyl)benzoic acid hydrochloride 
• 1093190-75-0 (2S,3R)-3-hydroxy-2-(4-(4-morpholin-4-ylmethylbenzylsulfanyl)benzoylamino)butyric acid methyl ester 

Relevant articles and documents

A Bifunctional Copper Catalyst Enables Ester Reduction with H2: Expanding the Reactivity Space of Nucleophilic Copper Hydrides

Employing a bifunctional catalyst based on a copper(I)/NHC complex and a guanidine organocatalyst, catalytic ester reductions to alcohols with H2 as terminal reducing agent are facilitated. The approach taken here enables the simultaneous activation of esters through hydrogen bonding and formation of nucleophilic copper(I) hydrides from H2, resulting in a catalytic hydride transfer to esters. The reduction step is further facilitated by a proton shuttle mediated by the guanidinium subunit. This bifunctional approach to ester reductions for the first time shifts the reactivity of generally considered "soft"copper(I) hydrides to previously unreactive "hard"ester electrophiles and paves the way for a replacement of stoichiometric reducing agents by a catalyst and H2.

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

One of the main obstacles toward the discovery of effective anti-Alzheimer drugs is the multifactorial nature of its etiopathology. Therefore, the use of multitarget-directed ligands has emerged as particularly suitable. Such ligands, able to modulate different neurodegenerative pathways, for example, amyloid and tau cascades, as well as cognitive and neurogenic functions, are fostered to come. In this respect, we report herein on the first class of BACE-1/GSK-3β dual inhibitors based on a 3,4-dihydro-1,3,5-triazin-2(1H)-one skeleton, whose hit compound 1 showed interesting properties in a preliminary investigation. Notably, compound 2, endowed with well-balanced potencies against the two isolated enzymes (IC50 of 16 and 7 μM against BACE-1 and GSK-3β, respectively), displayed effective neuroprotective and neurogenic activities and no neurotoxicity in cell-based assays. It also showed good brain permeability in a pharmacokinetic assessment in mice. Overall, triazinone derivatives, thanks to the simultaneous modulation of multiple points of the diseased network, might emerge as suitable candidates to be tested in in vivo Alzheimer's disease models.