912773-21-8

Basic information

• Product Name: 5-BROMO-2-CHLOROPYRAZINE
• Synonyms: 5-BROMO-2-CHLOROPYRAZINE;2-BROMO-5-CHLOROPYRAZINE;2-Bromo-5-chloro-1,4-diazine;2-Chloro-5-bromopyrazine
• CAS NO: 912773-21-8
• Molecular Formula: C₄H₂BrClN₂
• Molecular Weight: 193.43
• Product Categories: Building Blocks;Pyrazine
• Mol File: 912773-21-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.859
• Vapor Pressure: 0.313mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.53±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-2-CHLOROPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLOROPYRAZINE(912773-21-8)
• EPA Substance Registry System: 5-BROMO-2-CHLOROPYRAZINE(912773-21-8)

Safety Data

• Hazardous Substances Data: 912773-21-8(Hazardous Substances Data)

Usage

General Description

5-BROMO-2-CHLOROPYRAZINE is a chemical compound that belongs to the class of pyrazine derivatives. It is a white to off-white solid with a molecular formula of C4H2BrClN2. 5-BROMO-2-CHLOROPYRAZINE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the development of various research and laboratory applications. 5-BROMO-2-CHLOROPYRAZINE is known for its versatile and valuable properties, making it an important building block in the chemical and pharmaceutical industries.

InChI:InChI=1/C4H2BrClN2/c5-3-1-8-4(6)2-7-3/h1-2H

Upstream product

• 374063-92-0 2-hydroxy-5-bromopyrazine 

Downstream Products

• 955050-08-5 4-(5-bromopyrazin-2-yl)morpholine 

Relevant articles and documents

Favipiravir intermediate and synthesis method of favipiravir

The invention discloses a favipiravir intermediate and a synthesis method of favipiravir. The synthesis method comprises the following steps: taking 2,5-dihalopyrazine as an initial raw material, reacting 2,5-dihalopyrazine with formamide under the action of an oxide and a catalyst to generate 6-halo-3-chloro-2-amide pyrazine; carrying out a reaction on 6-halo-3-chloro-2-amide pyrazine under the action of a dehydration chlorinating agent and an acid-binding agent to generate a favipiravir intermediate 3,6-dichloro-3-cyanopyrazine; carrying out an aromatic ring fluorination reaction on the obtained favipiravir intermediate and potassium fluoride in dimethyl sulfoxide to generate 3,6-difluoro-3-cyanopyrazine; adding the 3,6-difluoro-3-cyanopyrazine into a water solution containing sodium acetate, and carrying out hydrolysis to obtain 6-fluoro-3-hydroxyl-2-cyanopyrazine; and finally, carrying out a cyano hydrolysis reaction to obtain favipiravir. A mixture of 2,5-dichloropyrazine and 2-chloro-5-bromopyrazine are used as raw materials to synthesize the favipiravir intermediate, the raw material cost is remarkably reduced, and the provided synthesis method has the technical advantages of high yield and low cost.