912923-82-1Relevant articles and documents
Pyridine amides as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Wang, Haixia,Ruan, Zheming,Li, James J.,Simpkins, Ligaya M.,Smirk, Rebecca A.,Wu, Shung C.,Hutchins, Robert D.,Nirschl, David S.,Van Kirk, Katy,Cooper, Christopher B.,Sutton, James C.,Ma, Zhengping,Golla, Rajasree,Seethala, Ramakrishna,Salyan, Mary Ellen K.,Nayeem, Akbar,Krystek Jr., Stanley R.,Sheriff, Steven,Camac, Daniel M.,Morin, Paul E.,Carpenter, Brian,Robl, Jeffrey A.,Zahler, Robert,Gordon, David A.,Hamann, Lawrence G.
scheme or table, p. 3168 - 3172 (2009/04/11)
Several series of pyridine amides were identified as selective and potent 11β-HSD1 inhibitors. The most potent inhibitors feature 2,6- or 3,5-disubstitution on the pyridine core. Various linkers (CH2SO2, CH2S, CH2/su
