91296-86-5

Basic information

• Product Name: Difluoxacin hydrochloride
• Synonyms: VETRANAL;6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-7-(4-METHYLPIPERAZINO)-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE;DIFLUOXACIN HYDROCHLORIDE;DIFLOXACIN HCL;DIFLOXACIN HYDROCHLORIDE;Difluoxacin HCL;3-Quinolinecarboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monohydrochloride;6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride
• CAS NO: 91296-86-5
• Molecular Formula: C₂₁H₁₉F₂N₃O₃*ClH
• Molecular Weight: 435.85
• EINECS: 1806241-263-5
• Product Categories: Active Pharmaceutical Ingredients;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;DICURAL
• Mol File: 91296-86-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: >245°C (dec.)
• Boiling Point: 595.5 °C at 760 mmHg
• Flash Point: 313.9 °C
• Appearance: off-white to pale yellow solid
• Density: 1.409 g/cm³
• Vapor Pressure: 5.01E-15mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: 0-6°C
• Solubility: Soluble in aqueous buffer
• CAS DataBase Reference: Difluoxacin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Difluoxacin hydrochloride(91296-86-5)
• EPA Substance Registry System: Difluoxacin hydrochloride(91296-86-5)

Safety Data

• WGK Germany: 3
• RTECS: VB2008975
• Hazardous Substances Data: 91296-86-5(Hazardous Substances Data)

Usage

Brand Name(s) in US

Dicural

Description

Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 91296-86-5 differently. You can refer to the following data:
1. antibacterial, DNA gyrase inhibitor
2. A quinolone antibacterial compound. Structurally related to norfloxacin
3. A fluoroquinolone antibacterial structurally related to norfloxacin.

InChI:InChI=1/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)

Upstream product

• 109-01-3 1-methyl-piperazine 

Relevant articles and documents

Preparation method of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative

The invention belongs to the field of pharmaceutical chemicals, relates to a preparation method of a quinolone carboxylic acid derivative or a phthalazinone carboxylic acid derivative, and particularly relates to a preparation method of a 7-substituted-3-quinolone carboxylic acid derivative or a 7-substituted-1,5-phthalazinone carboxylic acid derivative. The preparation method comprises the following steps: (1) in an organic solvent, carrying out coupling reaction on a boron chelate II and organic amine III in the presence of an organosilicon compound to obtain a compound IV; and (2) mixing the compound IV with hydrochloric acid, and then filtering and separating the precipitated compound I. Compared with conventional methods, the preparation method provided by the invention has the advantages that the conditions are milder, the hydrolysis of the substrate quinoline carboxylic acid boric acid ester can be reduced, and meanwhile, the influence of a byproduct HF on the product purity is avoided. The method is high in yield and high in purity; compared with the traditional alkali, the organic silicon is more suitable for industrial preparation of the 7-substituted-3-quinolone carboxylic acid derivative or the 7-substituted-1,5-phthalazinone carboxylic acid derivative.