91300-60-6 Usage
Description
6-ANILINO-5,8-QUINOLINEDIONE, also known as LY83583, is a chemical compound that exhibits various inhibitory properties. It is characterized by its ability to inhibit nitric-oxide-induced activation of soluble guanylate cyclase in a dose-dependent and reversible manner. Additionally, it blocks acetylcholine-induced vasorelaxation and acts as an inhibitor of antigen-induced leukotriene release.
Uses
Used in Pharmaceutical Industry:
6-ANILINO-5,8-QUINOLINEDIONE is used as an inhibitor of soluble guanylate cyclase and cGMP production for its potential therapeutic applications. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 μM, indicating its effectiveness in regulating cellular processes.
Used in Research Applications:
6-ANILINO-5,8-QUINOLINEDIONE is used as a research tool to study the role of nitric oxide and soluble guanylate cyclase in various biological processes. Its inhibitory properties allow researchers to investigate the effects of modulating these pathways on cell function and signaling.
Used in Inflammation and Immunology Research:
6-ANILINO-5,8-QUINOLINEDIONE is used as an inhibitor of leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 μM. This makes it a valuable compound for studying the role of leukotrienes in inflammation and immune responses.
Used in Enzyme Inhibition Studies:
6-ANILINO-5,8-QUINOLINEDIONE is used as a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 μM. This application aids in understanding the enzyme's function and its role in cellular redox balance and detoxification processes.
Check Digit Verification of cas no
The CAS Registry Mumber 91300-60-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,3,0 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 91300-60:
(7*9)+(6*1)+(5*3)+(4*0)+(3*0)+(2*6)+(1*0)=96
96 % 10 = 6
So 91300-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
91300-60-6Relevant articles and documents
Gold(III)-catalyzed 1,4-nucleophilic addition: Facile approach to prepare 2-amino-1,4-naphthalenedione and 6-amino-5,8-quinolinedione derivatives
Jiang, Chunhui,Wang, Shaozhong
experimental part, p. 1099 - 1102 (2009/10/14)
An efficient approach is developed to prepare different 2-amino-1,4-naphthalenedione and 6-amino-5,8-quinolinedione derivatives regioselectively by Au(III)-catalyzed 1,4-nucleophilic addition and subsequent oxidation. A wide variety of primary, secondary, and aromatic amines, as well as allylamine and 2-butynylamine are well tolerated under the mild conditions to give products in moderate to good yields. Georg Thieme Verlag Stuttgart.
