91344-69-3

Basic information

• Product Name: 1,4-Benzenediol, 2-(2-furanylmethyl)-
• CAS NO: 91344-69-3
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Mol File: 91344-69-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-Benzenediol, 2-(2-furanylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Benzenediol, 2-(2-furanylmethyl)-(91344-69-3)
• EPA Substance Registry System: 1,4-Benzenediol, 2-(2-furanylmethyl)-(91344-69-3)

Safety Data

• Hazardous Substances Data: 91344-69-3(Hazardous Substances Data)

Usage

Derivation

Dehydration of sugars

Physical state

Colorless liquid

Odor

Faint, sweet

Flammability

Flammable

Toxicity

Toxic if ingested

Uses

a. Solvent
b. Intermediate in organic synthesis
c. Production of resins and adhesives
d. Flavoring agent in food
e. Precursor to polymer materials

Industrial applications

a. Corrosion inhibitor
b. Rubber and plastic modifier
c. Fragrance ingredient in perfumes and cosmetics

Upstream product

• 98-01-1 furfural 
• 637-88-7 1,4-Cyclohexanedione 

Relevant articles and documents

Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the sarco/endoplasmic reticulum calcium ATPase

Analogues of the compound 2,5-di-tert-butylhydroquinone (BHQ) are capable of inhibiting the enzyme sarco/endoplasmic reticulum ATPase (SERCA) in the low micromolar and submicromolar concentration ranges. Not only are SERCA inhibitors valuable research tools, but they also have potential medicinal value as agents against prostate cancer. This study describes the synthesis of 13 compounds representing several classes of BHQ analogues, such as hydroquinones with a single aromatic substituent, symmetrically and unsymmetrically disubstituted hydroquinones, and hydroquinones with ω-amino acid tethers attached to their hydroxyl groups. Structure-activity relationships were established by measuring the inhibitory potencies of all synthesized compounds in bioassays. The assays were complemented by computational ligand docking for an analysis of the relevant ligand/receptor interactions.

A Convenient Synthesis of 2-Alkylated 1,4-Benzenediols

Reaction of 1,4-cyclohexanedione with a variety of aldehydes in the presence of metal halides generated the 2-alkylated 1,4-benzenediols in good yields without any aromatic by-products.