913488-45-6Relevant articles and documents
One-pot synthesis of highly functionalizable 3-(phenylsulfonyl)-2,3-dihydro-4(1H)-quinolinones via a Cu-catalyzed aza-Michael addition/cyclization reaction
Kang, Seongil,Yoon, Hongju,Lee, Yunmi
, p. 1356 - 1358 (2016)
A straightforward and mild one-pot method used for the synthesis of 3-(phenylsulfonyl)-2,3-dihydro-4(1H)-quinolinones via a Cu-catalyzed aza-Michael addition/base-mediated cyclization reaction is described. Addition of a range of readily available 2-aminobenzoates to phenyl vinyl sulfone was catalyzed by 5 mol% of a Cu complex at ambient temperature, followed by cyclization with KOt-Bu at 0°C to afford new versatile 3-sulfonyl-substituted-2,3-dihydro-4(1H)-quinolinones in good yield (53-99%).