913556-82-8

Basic information

• Product Name: 1,6-Naphthyridin-2(1H)-one, 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-, 6-oxide
• CAS NO: 913556-82-8
• Molecular Formula: C20H10Cl2F2N2O2
• Molecular Weight: 419.214
• Mol File: 913556-82-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,6-Naphthyridin-2(1H)-one, 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-, 6-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-Naphthyridin-2(1H)-one, 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-, 6-oxide(913556-82-8)
• EPA Substance Registry System: 1,6-Naphthyridin-2(1H)-one, 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-, 6-oxide(913556-82-8)

Safety Data

• Hazardous Substances Data: 913556-82-8(Hazardous Substances Data)

Upstream product

• 37511-45-8 N-2,6-dichlorophenyl-acrylamide 
• 14432-12-3 4-Amino-2-chloropyridine 
• 73583-37-6 2-chloro-4-bromopyridine 
• 916203-59-3 5-chloro-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one 
• 916203-52-6 4-bromo-2-chloro-3-iodo-pyridine 
• 444665-44-5 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2(1H)-one 

Downstream Products

• 872973-93-8 7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2-(1H)-one 

Relevant articles and documents

p38 MAP kinase inhibitors. Part 5: Discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold

A new sub-class of p38 inhibitors represented by 7-amino-naphthyridone have been discovered. Benchmark compound 16 potently inhibited p38 in vitro, was functionally active, and displayed excellent pharmacokinetic profiles in two animal species. Compound 1