913642-07-6

Basic information

• Product Name: 4-Pyridinamine, 2-bromo-N-ethyl-5-nitro-
• CAS NO: 913642-07-6
• Molecular Formula: C7H8BrN3O2
• Molecular Weight: 246.063
• Mol File: 913642-07-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Pyridinamine, 2-bromo-N-ethyl-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinamine, 2-bromo-N-ethyl-5-nitro-(913642-07-6)
• EPA Substance Registry System: 4-Pyridinamine, 2-bromo-N-ethyl-5-nitro-(913642-07-6)

Safety Data

• Hazardous Substances Data: 913642-07-6(Hazardous Substances Data)

Upstream product

• 31872-62-5 4-methoxy-3-nitro-pyridine 
• 607373-82-0 2-hydroxy-4-methoxy-5-nitro pyridine 
• 4487-57-4 2,4-dibromo-5-nitropyridine 
• 75-04-7 ethylamine 

Downstream Products

• 913642-20-3 1,1-dimethylethyl [2-({3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methyl-1-butyn-1-yl)-1H-imidazo[4,5-c]pyridin-6-yl]phenyl}amino)-2-oxoethyl]carbamate 
• 913642-18-9 4-(6-[3-(aminomethyl)phenyl]-1-ethyl-4-{1-[tris(1-methylethyl)silyl]-1H-pyrrol-3-yl}-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine 
• 913640-04-7 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-(3-aminophenyl)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 
• 913640-15-0 4-[6-[3-(aminomethyl)phenyl]-1-ethyl-4-(1H-pyrrol-3-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine 
• 913640-48-9 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-6-[(phenylmethyl)oxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol 

Relevant articles and documents

Aminofurazans as potent inhibitors of AKT kinase

AKT inhibitors containing an imidazopyridine aminofurazan scaffold have been optimized. We have previously disclosed identification of the AKT inhibitor GSK690693, which has been evaluated in clinical trials in cancer patients. Herein we describe recent efforts focusing on investigating a distinct region of this scaffold that have afforded compounds (30 and 32) with comparable activity profiles to that of GSK690693.

INHIBITORS OF AKT ACTIVITY

Invented are novel 1 H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.