913734-73-3Relevant articles and documents
Pd-Catalyzed Synthesis of Piperazine Scaffolds under Aerobic and Solvent-Free Conditions
Reilly, Sean W.,Mach, Robert H.
supporting information, p. 5272 - 5275 (2016/10/31)
A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiperazines under aerobic conditions is reported. Electron donating and sterically hindered aryl chlorides were aminated to afford yields up to 97%, with examples using piperazine as solvent, illustrating an ecofriendly, cost-effective synthesis of these privileged structures.
Syntheses and radiofluorination of two derivatives of 5-cyano-indole as selective ligands for the dopamine subtype-4 receptor
Tietze, Rainer,Hocke, Carsten,Loeber, Stefan,Huebner, Harald,Kuwert, Torsten,Gmeiner, Peter,Prante, Olaf
, p. 55 - 70 (2007/10/03)
Two fluoroethoxy substituted derivatives, namely 2-[4-(2-(2-fluoroethoxy) phenyl)-piperazin-1-ylmethyl]indole-5-carbonitrile (5a) and 2-[4-(4-(2- fluoroethoxy)-phenyl) piperazin-1-ylmethyl]indole-5-carbonitrile (Sb) were synthesized as analogs of the sele