91419-53-3

Basic information

• Product Name: N-Boc-3-Cyanopiperidine
• Synonyms: 1-N-BOC-PIPERIDINE-3-CARBONITRILE;(+/-)-1-N-BOC-3-CYANO-PIPERIDINE;1-N-BOC-3-CYANOPIPERIDINE;3-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-BOC-3-CYANO-PIPERIDINE;TERT-BUTYL-3-CYANOPIPERIDINE-1-CARBOXYLATE;1-Boc-3-cyanopiperidine;1-Boc-3-cyanopiperdine
• CAS NO: 91419-53-3
• Molecular Formula: C₁₁H₁₈N₂O₂
• Molecular Weight: 210.27
• Product Categories: Piperidine
• Mol File: 91419-53-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 60-65℃
• Boiling Point: 40°C/30mmHg(lit.)
• Flash Point: 150.5 °C
• Appearance: White to yellow/Powder
• Density: 1.07 g/cm³
• Vapor Pressure: 0.000232mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: -3.42±0.40(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: N-Boc-3-Cyanopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-3-Cyanopiperidine(91419-53-3)
• EPA Substance Registry System: N-Boc-3-Cyanopiperidine(91419-53-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-36/37/38-50
• Safety Statements: 26-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 91419-53-3(Hazardous Substances Data)

Usage

General Description

N-Boc-3-Cyanopiperidine is a chemical compound that belongs to the class of piperidine derivatives. It is a white to off-white solid that is commonly used in organic synthesis, particularly in the pharmaceutical industry for the production of various drugs. The "N-Boc" in its name stands for N-tert-butoxycarbonyl, a protecting group used in organic chemistry to temporarily mask reactive functional groups. N-Boc-3-Cyanopiperidine is known for its use in the preparation of N-Boc-3-aminopiperidine, which is a key intermediate in the synthesis of various pharmaceuticals. N-Boc-3-Cyanopiperidine is typically handled and stored under controlled conditions, as it can be hazardous if not properly managed.

InChI:InChI=1/C11H18N2O2/c1-11(2,3)15-10(14)13-6-4-5-9(7-12)8-13/h9H,4-6,8H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 498-95-3 nipecotic acid 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 91419-49-7 tert-butyl 3-carbamoylpiperidine-1-carboxylate 

Downstream Products

• 940868-22-4 tert-butyl 3-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)piperidine-1-carboxylate 

Relevant articles and documents

Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes

Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination step, thereby dramatically increasing the rate of the overall transformation relative to alternative metal-catalyzed systems. This new reaction proceeds at ambient temperature, tolerates a variety of metal-, acid-, or base-sensitive functional groups, and can be performed using a simple ligand, inexpensive siloxanes, and low catalyst loading.

Carbazole inhibitors of histamine receptors for the treatment of disease

The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

NEW COMPOUNDS

The present invention relates to new compounds of formula (I) wherein Y1 and Y2 selected from the group consisting of hydrogen, halogen atom; C1-4 alkyl, C1-4alkoxy, cyano and trifluoromethyl group, Q is -CH- gr