91427-06-4

Basic information

• Product Name: Ethanone, 1-[4-(3-chloropropyl)phenyl]-
• CAS NO: 91427-06-4
• Molecular Formula: C11H13ClO
• Molecular Weight: 196.677
• Mol File: 91427-06-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-(3-chloropropyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(3-chloropropyl)phenyl]-(91427-06-4)
• EPA Substance Registry System: Ethanone, 1-[4-(3-chloropropyl)phenyl]-(91427-06-4)

Safety Data

• Hazardous Substances Data: 91427-06-4(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-[4-(3-chloropropyl)phenyl]-, also known as Clavoacetophenone, is a chemical compound that belongs to the family of organic compounds known as aromatic ketones. It is commonly used as a perfume and flavoring ingredient due to its sweet, floral, and woody odor. This chemical is also used as a precursor in the synthesis of pharmaceuticals and other organic compounds. Additionally, it has been studied for its potential antimicrobial and antifungal properties, making it a valuable compound in the field of medicinal chemistry. However, it is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system if not properly managed.

Upstream product

• 104-52-9 phenylpropyl chloride 
• 75-36-5 acetyl chloride 
• 10537-63-0 1-(4-vinylphenyl)ethanone 
• 123655-43-6 C₁₁H₁₅ClO 
• 109613-00-5 4-acetophenyl triflate 

Downstream Products

• 1356411-42-1 1-{4-[3-(dibutylamino)propyl]phenyl}ethanone 
• 401925-43-7 isopropyl 2-butyl-3-{4-[3-(dibutylamino)propyl]benzoyl}-1-benzofuran-5-carboxylate 
• 1356411-41-0 1-{4-[3-(dibutylamino)propyl]phenyl}heptane-1,3-dione 

Relevant articles and documents

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

A benchtop stable, bifunctional reagent for the redox-neutral cyclopropanation of olefins has been developed. Triethylammonium bis(catecholato)iodomethylsilicate can be readily prepared on multigram scale. Using this reagent in combination with an organic photocatalyst and visible light, cyclopropanation of an array of olefins, including trifluoromethyl- and pinacolatoboryl-substituted alkenes, can be accomplished in a matter of hours. The reaction is highly tolerant of traditionally reactive functional groups (carboxylic acids, basic heterocycles, alkyl halides, etc.) and permits the chemoselective cyclopropanation of polyolefinated compounds. Mechanistic interrogation revealed that the reaction proceeds via a rapid anionic 3-exo-tet ring closure, a pathway consistent with experimental and computational data.

One-pot synthesis of carbamoyl azides directly from primary alcohols and oxidation of secondary alcohols to ketones using iodobenzene dichloride in combination with sodium azide

An effective synthesis of carbamoyl azides directly from primary alcohols using iodobenzene dichloride in combination with sodium azide has been developed. Moreover, the same regent combination was also efficient for the oxidation of secondary alcohols to the corresponding ketones.

B-alkyl suzuki-miyaura cross-coupling reactions with air-stable potassium alkyltrifluoroborates

The palladium-catalyzed cross-coupling reaction of substituted potassium alkyltrifluoroborates with aryl halides and aryl triflates proceeds readily with moderate to good yields. The potassium alkyltrifluoroborates 1, 2, and 3a-e were easily synthesized and obtained as air-stable crystalline solids that can be stored for long periods of time. All of the cross-couplings proceed under the same reaction conditions using PdCl2(dppf)·CH2cl2 as catalyst in THF-H2O in the presence of 3 equiv of Cs2CO3 as base.