914299-22-2 Usage
General Description
The chemical 2-(3-methoxycarbonyl-2-methyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester is a compound with a pyrrolidine ring and a carboxylic acid group. It also contains a tert-butyl ester group, which is a type of functional group derived from tert-butanol. 2-(3-METHOXYCARBONYL-2-METHYL-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER may have potential applications in the pharmaceutical and chemical industries, as it could exhibit biological activities or be used as a building block for the synthesis of other compounds. Due to its structural features, it may also have specific properties and reactivity that make it suitable for certain reactions or processes. Further research and testing may be needed to fully understand the chemical and its potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 914299-22-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,2,9 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 914299-22:
(8*9)+(7*1)+(6*4)+(5*2)+(4*9)+(3*9)+(2*2)+(1*2)=182
182 % 10 = 2
So 914299-22-2 is a valid CAS Registry Number.
914299-22-2Relevant articles and documents
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
Kung, Pei-Pei,Funk, Lee,Meng, Jerry,Collins, Michael,Zhou, Joe Zhongxiang,Catherine Johnson,Ekker, Anne,Wang, Jeff,Mehta, Pramod,Yin, Min-Jean,Rodgers, Caroline,Davies II, Jay F.,Bayman, Eileen,Smeal, Tod,Maegley, Karen A.,Gehring, Michael R.
supporting information; experimental part, p. 6273 - 6278 (2009/08/15)
Information from X-ray crystal structures were used to optimize the potency of a HTS hit in a Hsp90 competitive binding assay. A class of novel and potent small molecule Hsp90 inhibitors were thereby identified. Enantio-pure compounds 31 and 33 were potent in PGA-based competitive binding assay and inhibited proliferation of various human cancer cell lines in vitro, with IC50 values averaging 20 nM.
