914311-50-5 Usage
Description
3-AMINO-4-BROMO-1H-INDAZOLE is a chemical compound derived from the 1H-indazole family, characterized by the presence of an amino group at the 3-position and a bromine atom at the 4-position. This structural feature endows it with unique chemical and biological properties, making it a versatile molecule for various applications in different fields.
Uses
Used in Organic Synthesis:
3-AMINO-4-BROMO-1H-INDAZOLE is used as a synthetic intermediate for the preparation of various organic compounds. Its amino and bromo substituents allow for further functionalization and modification, enabling the synthesis of a wide range of molecules with diverse properties and applications.
Used in Pharmaceutical Industry:
3-AMINO-4-BROMO-1H-INDAZOLE is used as a building block for the development of pharmaceutical compounds. Its unique structure and reactivity make it a promising candidate for the design and synthesis of new drugs with potential therapeutic applications.
Used in Chemical Research:
3-AMINO-4-BROMO-1H-INDAZOLE is used as a research tool in chemical investigations. Its distinct chemical properties and reactivity provide valuable insights into various chemical processes and reactions, contributing to the advancement of chemical knowledge and understanding.
Synthesis:
3-AMINO-4-BROMO-1H-INDAZOLE can be synthesized through a series of reactions starting from 2-halobenzaldehydes or 2-haloacetophenones. Microwave heating of these compounds with phenylhydrazines at 160°C for 10 minutes quantitatively yields the arylhydrazones. These arylhydrazones can then be cyclized to form 1-aryl-1H-indazoles via CuI/diamine-catalyzed N-arylation under microwave heating (160°C, 10 minutes). This method provides good to excellent yields for 2-iodo, 2-bromo, and 2-chloro benzaldehydes or acetophenones, making it a reliable and efficient synthetic route for the production of 3-AMINO-4-BROMO-1H-INDAZOLE and its derivatives.
Check Digit Verification of cas no
The CAS Registry Mumber 914311-50-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,3,1 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 914311-50:
(8*9)+(7*1)+(6*4)+(5*3)+(4*1)+(3*1)+(2*5)+(1*0)=135
135 % 10 = 5
So 914311-50-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BrN3/c8-4-2-1-3-5-6(4)7(9)11-10-5/h1-3H,(H3,9,10,11)
914311-50-5Relevant articles and documents
Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
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Page/Page column 361, (2016/04/26)
The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.
COMBINATION OF KINASE INHIBITORS AND USES THEREOF
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Paragraph 00641, (2014/10/04)
The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.
New practical synthesis of indazoles via condensation of o-fluorobenzaldehydes and their O-methyloximes with hydrazine
Lukin, Kirill,Hsu, Margaret C.,Fernando, Dilinie,Leanna, M. Robert
, p. 8166 - 8172 (2007/10/03)
The reaction of o-fluorobenzaldehydes and their O-methyloximes with hydrazine has been developed as a new practical synthesis of indazoles. Utilization of the methyloxime derivatives of benzaldehydes (in the form of the major E-isomers) in this condensation effectively eliminated a competitive Wolf-Kishner reduction to fluorotoluenes, which was observed in the direct preparations of indazoles from aldehydes. Reaction of Z-isomers of methyloximes with hydrazine resulted in the formation of 3-aminoindazoles via a benzonitrile intermediate.
