914360-74-0Relevant articles and documents
Highly selective substitutions in 2,3-dichloropyrazine. A novel general approach to aloisines
Chekmarev, Dmitriy S.,Shorshnev, Sergey V.,Stepanov, Alexander E.,Kasatkin, Alexander N.
, p. 9919 - 9930 (2007/10/03)
A highly efficient synthesis of the potent CDKs (cyclin-dependent kinases) inhibitors, aloisines (substituted 5H-pyrrolo[2,3-b]pyrazines) is presented. The method is based on highly selective monosubstitution of a single chlorine atom in 2,3-dichloropyraz