914360-82-0Relevant articles and documents
Diversity-oriented synthesis of bicyclic fragments containing privileged azines
Luise, Nicola,Wyatt, Paul G.
supporting information, p. 248 - 251 (2018/11/30)
An innovative and efficient reagent- and scaffold-based diversity oriented synthesis (DOS) of a fragment set was developed for fragment-based drug discovery (FBDD) programs. Twelve diverse, functionalized and bicyclic scaffolds were rapidly accessed by adopting a convenient synthetic toolkit around three privileged azine cores in order to effectively modulate biomolecules. These structures are characterized by both key motifs for interacting with diverse biological targets via hydrogen bonds and useful points of growth for subsequent fragment optimization.
FAK AND FLT3 INHIBITORS
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Page/Page column 126-127, (2014/03/22)
The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.
HERBICIDAL COMPOUNDS
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Page/Page column 38, (2012/05/31)
The present invention provides a compound of formula (I) wherein R4 is of sub-formula (a) or (b) and wherein the other substituents are as defined in the specification. The compounds of formula (I) are potentially useful as herbicides.