914453-95-5 Usage
Description
Atosiban acetate is a nonapeptide competitive vasopressin/oxytocin receptor antagonist and a desamino-oxytocin analogue. It is the primary tocolytic agent used in the management of preterm labor and has potential applications in spontaneous preterm labor research.
Uses
Used in Pharmaceutical Industry:
Atosiban acetate is used as a tocolytic agent for the management of preterm labor. It works by competitively blocking the vasopressin and oxytocin receptors, thereby inhibiting uterine contractions and delaying the onset of labor.
Used in Obstetrics and Gynecology:
Atosiban acetate is used as a therapeutic intervention in obstetrics and gynecology to prevent preterm birth. It helps in reducing the risk of complications associated with premature delivery and provides time for the administration of corticosteroids to promote fetal lung maturation.
Used in Preterm Labor Research:
Atosiban acetate is used as a research tool in the study of spontaneous preterm labor. It aids in understanding the mechanisms underlying preterm labor and the development of new therapeutic strategies to prevent or manage this condition.
storage
Dry, dark and at 0-4℃ for short term (days to weeks) or -20℃ for long term (months to years).
references
[1] borthwick a d. oral oxytocin antagonists. journal of medicinal chemistry, 2010, 53(18): 6525-6538.[2] reversi a, rimoldi v, marrocco t, et al. the oxytocin receptor antagonist atosiban inhibits cell growth via a “biased agonist” mechanism. journal of biological chemistry, 2005, 280(16): 16311-16318.
Check Digit Verification of cas no
The CAS Registry Mumber 914453-95-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,4,5 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 914453-95:
(8*9)+(7*1)+(6*4)+(5*4)+(4*5)+(3*3)+(2*9)+(1*5)=175
175 % 10 = 5
So 914453-95-5 is a valid CAS Registry Number.
InChI:InChI=1S/C43H67N11O12S2.C2H4O2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2;1-2(3)4/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63);1H3,(H,3,4)/t23-,24+,27-,28+,29-,30-,31-,35-,36?;/m0./s1