914460-61-0Relevant articles and documents
2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists
Jiang, Jinlong,Hoang, Myle,Young, Jonathan R.,Chaung, Danny,Eid, Ronsar,Turner, Cherilyn,Lin, Peter,Tong, Xinchun,Wang, Junying,Tan, Carina,Feighner, Scott,Palyha, Oksana,Hreniuk, Donna L.,Pan, Jie,Sailer, Andreas W.,MacNeil, Douglas J.,Howard, Andrew,Shearman, Lauren,Stribling, Sloan,Camacho, Ramon,Strack, Alison,Van der Ploeg, Lex H.T.,Goulet, Mark T.,DeVita, Robert J.
, p. 5270 - 5274 (2007/10/03)
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.
