914617-29-1Relevant articles and documents
Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue
Tomlinson, John T.,Park, Gyungse,Misenheimer, Jacob A.,Kucera, Gregory L.,Hesp, Kevin,Manderville, Richard A.
, p. 4951 - 4954 (2006)
(Chemical Equation Presented) The prodigiosin alkaloid 1 and the synthetic analogue 2 show photoinduced cytotoxicity against HL-60 cancer cells. Photoirradiation of 1 and 2 causes photofading, photooxidation, and thioadduct formation. These results provide a model for the redox properties of prodigiosins that play a role in their biological activity and provide a new way to functionalize their pyrromethene entity with water-soluble thiol groups.