915019-50-0

Basic information

• Product Name: Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-
• Synonyms: Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-;2-(4-(8-broMo-3-Methyl-2-oxo-2,3-dihydro-1H-iMidazo[4,5-c]quinolin-1-yl)phenyl)-2-Methylpropanenitrile;Benzeneacetonitrile, 4-(8-broMo-2,3-dihydro-3-Methyl-2-oxo-1H-iMidazo[4,5-c]quinolin-1-yl)-a,a-diMethyl-;2-[4-(8-Bromo-3-methyl-2-oxo-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl]-2-methylpropionitrile;2-[4-(3-Amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile
• CAS NO: 915019-50-0
• Molecular Formula: C₂₁H₁₇BrN₄O
• Molecular Weight: 421.28988
• Mol File: 915019-50-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 598.8°C at 760 mmHg
• Flash Point: 316°C
• Appearance: /
• Density: 1.478g/cm³
• Vapor Pressure: 2.67E-14mmHg at 25°C
• Refractive Index: 1.678
• PKA: 6.19±0.20(Predicted)
• CAS DataBase Reference: Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-(915019-50-0)
• EPA Substance Registry System: Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl-(915019-50-0)

Safety Data

• Hazardous Substances Data: 915019-50-0(Hazardous Substances Data)

Usage

General Description

Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl- is a complex chemical compound with a molecular structure containing benzene, acetonitrile, and a combination of other elements. This chemical may have potential applications in the pharmaceutical industry due to its unique molecular structure, which includes a quinolin-1-yl group and a bromine atom. Additionally, the compound's alpha, alpha-dimethyl groups can affect the compound's reactivity and bioavailability in various applications. Further research is necessary to understand and leverage the potential properties and applications of Benzeneacetonitrile, 4-(8-bromo-2,3-dihydro-3-methyl-2-oxo-1H-imidazo[4,5-c]quinolin-1-yl)-.alpha.,.alpha.-dimethyl- in different industries.

InChI:InChI=1/C21H17BrN4O/c1-21(2,12-23)13-4-7-15(8-5-13)26-19-16-10-14(22)6-9-17(16)24-11-18(19)25(3)20(26)27/h4-11H,1-3H3

Upstream product

• 915019-53-3 2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 77-78-1 dimethyl sulfate 
• 1201643-75-5 (E)-5-bromo-2-((2-nitrovinyl)amino)benzoic acid 
• 853908-49-3 5-bromo-2-((2-nitroethenyl)amino)benzoic acid 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 915019-52-2 2-[4-(3-amino-6-bromo-quinolin-4-ylamino)-phenyl]-2-methyl-propionitrile 
• 915019-51-1 2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile 
• 115279-57-7 2-(4-aminophenyl)-2-methylpropionitrile 
• 71825-51-9 4-(2-cyanoprop-2-yl)-1-nitrobenzene 
• 723281-72-9 6-bromo-4-chloro-3-nitroquinoline 
• 853908-50-6 6-bromo-3-nitroquinolin-4-ol 
• 74-88-4 methyl iodide 
• 74189-16-5 2-amino-5-bromobenzoic acid hydrochloride 

Downstream Products

• 1610680-69-7 2-methyl-2-(4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 915019-65-7 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile 
• 853910-61-9 NVP-BBD₁₃₀ 

Relevant articles and documents

Development of a Robust Synthesis of Dactolisib on a Commercial Manufacturing Scale

The development of the robust synthesis of 2-methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]-phenyl]propionitrile (dactolisib) on a commercial scale is described. The key step is a Pd-catalyzed Suzuki coupling of 2-[4-(8-bromo-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)-phenyl]-2-methyl-propionitrile to 3-quinoline boronic acid. A special focus is placed on reducing the amount of Pd catalyst used in the Suzuki coupling and purifying the crude drug substance, including removing traces of Pd.

Acid-Promoted Cascade Reaction of N-(4-Chloroquinolin-3-yl)carbamates with Amines: One-Pot Assembly of Imidazo[4,5-c]quinolin-2-ones

An acid-promoted cascade reaction of N-(4-chloroquinolin-3-yl)carbamates with amines is described. This method achieves the formation of two new C–N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination wit

RAPAMYCIN ANALOGS AS MTOR INHIBITORS

The present disclosure relates to rapamycin analogs of the general Formula (I). The compounds are inhibitors of mTOR and thus useful for the treatment of cancer, immune-mediated diseases and age related conditions.