915199-14-3

Basic information

• Product Name: 4-(1-AZETIDINE CARBONYL)-BENZOIC ACID METHYL ESTER
• Synonyms: 4-(1-AZETIDINE CARBONYL)-BENZOIC ACID METHYL ESTER
• CAS NO: 915199-14-3
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 0
• Mol File: 915199-14-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1-AZETIDINE CARBONYL)-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-AZETIDINE CARBONYL)-BENZOIC ACID METHYL ESTER(915199-14-3)
• EPA Substance Registry System: 4-(1-AZETIDINE CARBONYL)-BENZOIC ACID METHYL ESTER(915199-14-3)

Safety Data

• Hazardous Substances Data: 915199-14-3(Hazardous Substances Data)

Upstream product

• 503-29-7 azetidine 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 78797-58-7 azetidine hydrochloride 

Downstream Products

• 915199-15-4 4-(azetidin-1-ylcarbonyl)benzoic acid 

Relevant articles and documents

Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities

In this study, we report the design and synthesis of a series of novel thiophene-arylamide compounds derived from the noncovalent decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) inhibitor TCA1 through a structure-based scaffold hopping strategy. Systematic optimization of the two side chains flanking the thiophene core led to new lead compounds bearing a thiophene-arylamide scaffold with potent antimycobacterial activity and low cytotoxicity. Compounds 23j, 24f, 25a, and 25b exhibited potent in vitro activity against both drug-susceptible (minimum inhibitory concentration (MIC) = 0.02-0.12 μg/mL) and drug-resistant (MIC = 0.031-0.24 μg/mL) tuberculosis strains while retaining potent DprE1 inhibition (half maximal inhibitory concentration (IC50) = 0.2-0.9 μg/mL) and good intracellular antimycobacterial activity. In addition, these compounds showed good hepatocyte stability and low inhibition of the human ether-à-go-go related gene (hERG) channel. The representative compound 25a with acceptable pharmacokinetic property demonstrated significant bactericidal activity in an acute mouse model of tuberculosis. Moreover, the molecular docking study of template compound 23j provides new insight into the discovery of novel antitubercular agents targeting DprE1.

4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists

A series of ketopiperazines were prepared and evaluated for their activity as histamine H3 antagonists. From investigation of the tertiary basic center in the aminopropyloxyphenyl template, the 2(R)-methylpyrrolidine was identified as the most

SUBSTITUTED PIPERIDINE ANTAGONIST OF HI RECEPTOR TO BE USED FOR THE TREATMENT OF RHINITIS

The present invention relates to the compound, (I) and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various disorders, such as allergic rhinitis.