915226-43-6

Basic information

• Product Name: 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-
• Synonyms: 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-;(R)-1-Boc-3-piperidinecarboxaMide;(R)-1-Boc-3-(aMinocarbonyl)-piperidine;(R)-tert-Butyl 3-carbaMoylpiperidine-1-carboxylate
• CAS NO: 915226-43-6
• Molecular Formula: C11H20N2O3
• Molecular Weight: 228.29
• Mol File: 915226-43-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 384.4±31.0 °C(Predicted)
• Appearance: /
• Density: 1.123±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 16.41±0.20(Predicted)
• CAS DataBase Reference: 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-(915226-43-6)
• EPA Substance Registry System: 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-(915226-43-6)

Safety Data

• Hazardous Substances Data: 915226-43-6(Hazardous Substances Data)

Usage

General Description

The chemical "1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-" is a complex organic compound that belongs to the class of piperidinecarboxylic acids and their derivatives. It is represented by the molecular formula C11H21N2O3. 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)- incorporates a piperidine ring which is a saturated heterocyclic ring comprising of five carbon atoms and one nitrogen atom. The nitrogen atom and one of the carbon atoms are connected by a carboxyl group with an amino carbonyl substituent. Also, the compound contains a t-butoxycarbonyl (BOC) group acting as a protecting group for the amino group during chemical synthesis. The symbol (3R)- indicates the specific spatial arrangement of atoms in the molecule, meaning that it has a certain chiral center at the 3-position on the piperidine ring which is configured as R.

Upstream product

• 4138-26-5 nipecotamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 163438-09-3 (R)-1-Boc-nipecotic acid 

Downstream Products

• 915226-44-7 (R)-3-cyano-piperidine-1-carboxylic acid tert-butyl ester 
• 188111-79-7 tert-butyl (3R)3-aminopiperidine-1-carboxylate 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE 3-AMINOPIPERIDINE OR SALT THEREOF

The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.

Compounds and Compositions as Channel Activating Protease Inhibitors

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.