91524-15-1

Basic information

• Product Name: Irloxacin
• Synonyms: Irloxacin;pirfloxacin;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-3-quinolinecarboxylic acid;1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)quinoline-3-carboxylic acid;E-3432
• CAS NO: 91524-15-1
• Molecular Formula: C16H13FN2O3
• Molecular Weight: 300.288
• Mol File: 91524-15-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 495.9°Cat760mmHg
• Flash Point: 253.7°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 1.18E-10mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: Irloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: Irloxacin(91524-15-1)
• EPA Substance Registry System: Irloxacin(91524-15-1)

Safety Data

• Hazardous Substances Data: 91524-15-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H13FN2O3/c1-2-18-9-11(16(21)22)15(20)10-7-12(17)14(8-13(10)18)19-5-3-4-6-19/h3-9H,2H2,1H3,(H,21,22)

Upstream product

• 73510-05-1 dimethoxytetrahydrofuran 
• 75001-63-7 6-fluoro-7-amino-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 96623-76-6 diethyl 4-fluoro-3-(1H-pyrrol-1-yl)anilinomethylenemalonate 
• 96623-78-8 6-fluoro-4-hydroxy-7-(1H-pyrrol-1-yl)quinoline-3-carboxylic acid 
• 96623-75-5 4-fluoro-3-(1H-pyrrol-1-yl)nitrobenzene 
• 158533-30-3 ethyl 6-fluoro-4-hydroxy-7-(1H-pyrrol-1-yl)quinoline-3-carboxylic acid 
• 369-36-8 6-fluoro-3-nitroaniline 
• 103060-76-0 7-acetilamino-6-fluoro-4-idrossichinolin-3-carbossilato di etile 
• 113595-97-4 3-acetilamino-4-fluoroanilinometilenemalonato dietilico 
• 75001-47-7 N-(5-amino-2-fluorophenyl)acetamide 
• 91188-89-5 7-amino-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 99727-00-1 7-acetilamino-1-etil-6-fluoro-1,4-diidrochinolin-4-on-3-carbossilato di etile 
• 454-07-9 N-(2-fluoro-5-nitrophenyl)acetamide 
• 96623-79-9 ethyl 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)quinoline-3-carboxylic acid 

Relevant articles and documents

New Structure-Activity Relationships of the Quinolone Antibacterials Using the Target Enzyme. The Development and Application of a DNA Gyrase Assay

A series of 60 newly synthesized and known quinolone antibacterials, including quinoline- and 1,8-naphthyridine-3-carboxylic acids, pyridopyrimidine-6-carboxylic acids, and some monocyclic 4-pyridone-3-carboxylic acids, were tested and compared in a newly established, easy to perform, DNA gyrase assay.The results were correlated with minimum inhibitory concentracions (MICs) against a variety of organisms.Among the known quinolones were 14 clinically significant drugs (oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, etc.) which were used as standards and compared side- by-side.The study focused on the changes in DNA gyrase inhibition brought about by certain features of the molecules, namely, the C6-fluorine or the nature of the C7 substituent.The intrinsic gyrase inhibition of the fused parent rings, quinoline vs. naphthyridine vs. pyridopyrimidine, was also explored.In all cases, loss of enzyme inhibition produced poor MICs, but some compounds with good DNA gyrase inhibition did not correspondingly inhibit bacterial growth.Possible explanations for this phenomena and the benefits of a DNA gyrase-MIC strategy for developing future structure-activity relationships are discussed.

Research on antifungal and antibacterial agents. VI. Pirfloxacin and related compounds: Synthetic and microbiological studies

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1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1H-pyrrol-1-yl)-quinoline-3-carboxylic acid, a new fluorinated compound of oxacin family with high broad-spectrum antibacterial activities

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