915307-78-7

Basic information

• Product Name: N-Boc-2-Chloro-4-fluoro-5-pyridinamine
• Synonyms: N-Boc-2-Chloro-4-fluoro-5-pyridinamine;tert-Butyl N-(6-chloro-4-fluoro-3-pyridinyl)-carbamate;5-Amino-2-chloro-4-fluoropyridine, 5-BOC protected;tert-butyl (6-chloro-4-fluoropyridin-3-yl)carbamate;Carbamic acid, N-(6-chloro-4-fluoro-3-pyridinyl)-, 1,1-dimethylethyl ester
• CAS NO: 915307-78-7
• Molecular Formula: C10H12ClFN2O2
• Molecular Weight: 246.6658832
• Mol File: 915307-78-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 272.934°C at 760 mmHg
• Flash Point: 118.866°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: N-Boc-2-Chloro-4-fluoro-5-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-2-Chloro-4-fluoro-5-pyridinamine(915307-78-7)
• EPA Substance Registry System: N-Boc-2-Chloro-4-fluoro-5-pyridinamine(915307-78-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 915307-78-7(Hazardous Substances Data)

Usage

General Description

N-boc-2-chloro-4-fluoro-5-pyridinamine is a chemical compound with the molecular formula C11H11ClFN2O2. It is a fluorescent and aromatic compound that is commonly used in organic synthesis and pharmaceutical research. The compound is a derivative of pyridine and has a Boc (tert-butoxycarbonyl) protecting group attached to the nitrogen atom. It is often utilized as a building block in the preparation of various biologically active molecules and pharmaceuticals. The chlorine and fluorine atoms in the compound contribute to its unique chemical and physical properties, making it a valuable tool in the development of new drugs and chemical compounds.

InChI:InChI=1/C10H12ClFN2O2/c1-10(2,3)16-9(15)14-7-5-13-8(11)4-6(7)12/h4-5H,1-3H3,(H,14,15)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 171178-45-3 tert-butyl (6-chloropyridin-3-yl)carbamate 

Downstream Products

• 915307-81-2 3,7-dichloro-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one 
• 954138-07-9 3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl) piperazin-l-yl]7-(6-methoxypyridin-3-yl)-l-(2-propoxyethyl)pyrido[3,4-b] pyrazin-2(lH)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)

We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-l-yl]7-(6-methoxypyridin-3-yl)- l-(2-propoxyethyl)pyrido[3,4-è]pyrazin-2(l//)-one, which possessed an excellent potency and selectivity profile and demonstrated robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Furthermore, this compound is brain penetrant and will be a useful agent for evaluating the therapeutic potential of central inhibition of PDE5. This compound has recently entered clinical trials.

Pyridine [3,4-b] Pyrazinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.