91539-40-1Relevant articles and documents
Cobalt-Catalyzed Decarboxylative Methylation and Ethylation of Aliphatic N-(Acyloxy)phthalimides with Organoaluminum Reagents
Wang, Ze-Zhong,Wang, Guang-Zu,Zhao, Bin,Shang, Rui,Fu, Yao
supporting information, p. 1221 - 1225 (2020/08/17)
A cobalt-catalyzed decarboxylative methylation of aliphatic redox-active esters [ N-(acyloxy)phthalimides; RAEs] with trimethylaluminum under mild conditions was developed, providing a method for transforming a carboxylate group into a methyl group without redox fluctuation. Primary and secondary RAEs were both amenable substrates, whereas a tertiary RAE delivered an elimination product. Triethylaluminum was also used to deliver a decarboxylative ethylation product.
5-Exo versus 6-Endo cyclization of primary aminyl radicals: An experimental and theoretical investigation
Liu, Feng,Liu, Kun,Yuan, Xinting,Li, Chaozhong
, p. 10231 - 10234 (2008/09/17)
(Chemical Equation Presented) The cyclization of neutral primary pent-4-enylaminyl radicals was investigated experimentally and theoretically. Unlike the corresponding secondary aminyl radicals, primary pent-4-enylaminyl radicals underwent efficient cyclization to afford the pyrrolidine and/or piperidine products in good to high yields. While the simple pent-4-enylaminyl radical gave predominately the 5-exo cyclization product, 4-chloropent-4- enylaminyl radicals led to the formation of the corresponding 6-endo cyclization products in excellent regioselectivity. Theoretical calculations revealed that the 5-exo cyclization rate of primary aminyl radicals is about 3-4 orders of magnitude higher than that of secondary aminyl radicals.
Circular Dichroism of Some N-Monosubstituted and N,N-Disubstituted Benzamides
Ringdahl, Bjoern
, p. 141 - 152 (2007/10/02)
The circular dichroism (CD) spectra of some N-benzoyl-1-alkyl-2-propynylamines and N-benzoyl-1-alkyl-2-propenylamines show three Cotton effects (CE's) in the near ultraviolet region.These are assigned to 1Lb, n->?* and 1La transitions of the N-monosubstituted benzamide chromophore.The 1Lb and n->?* CE's are negative and positive, respectively, for the R configuration.In the N-benzoyl-1-alkyl-2-propenylamines, the 1La CE's appear to be developed primarily through dipole - dipole coupling between allowed (?-?*) transitions of the benzamide chromophore and the ethenyl group.The benzoyl derivatives of some 2- and 3-substituted pyrrolidines also exhibit three CE's which are assigned to 1Lb n->?* and 1La transitions of the N,N-substituted benzamide chromophore.In benzoyl derivatives of 2-substituted pyrrolidines, these CE's are negative, positive and negative, respectively, for the D-proline configuration.The effect of increasing nonplanarity of the phenyl and amide groups, brought about by ortho-methyl substitution, on the CD behaviour of both N-monosubstituted and N,N-disubstituted benzamides is discussed.
