915731-88-3 Usage
General Description
The chemical compound [4-(2,4-Dichlorophenyl)-6-dimethylcarbamoylmethyl-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylmethyl]carbamic acid tert-butyl ester is a complex organic compound. It contains a tert-butyl ester group, a carbamic acid group, and multiple aromatic and heterocyclic rings. The compound also contains chlorine atoms attached to a phenyl group. The presence of various functional groups and complex ring structures suggests that this compound may have potential pharmaceutical or biological applications. Due to its complex structure, it may also be used as a building block in organic synthesis or medicinal chemistry for the development of new drugs or pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 915731-88-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,7,3 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 915731-88:
(8*9)+(7*1)+(6*5)+(5*7)+(4*3)+(3*1)+(2*8)+(1*8)=183
183 % 10 = 3
So 915731-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H28Cl2N4O4/c1-13-16(10-27-23(33)34-24(2,3)4)20(15-8-7-14(25)9-17(15)26)21-18(28-13)11-30(22(21)32)12-19(31)29(5)6/h7-9H,10-12H2,1-6H3,(H,27,33)
915731-88-3Relevant articles and documents
Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b] pyridin-6(7H)-yl)-N, N-dimethylacetamide (BMS-767778)
Devasthale, Pratik,Wang, Ying,Wang, Wei,Fevig, John,Feng, Jianxin,Wang, Aiying,Harrity, Tom,Egan, Don,Morgan, Nathan,Cap, Michael,Fura, Aberra,Klei, Herbert E.,Kish, Kevin,Weigelt, Carolyn,Sun, Lucy,Levesque, Paul,Moulin, Frederic,Li, Yi-Xin,Zahler, Robert,Kirby, Mark S.,Hamann, Lawrence G.
, p. 7343 - 7357 (2013/10/21)
Optimization of a 5-oxopyrrolopyridine series based upon structure-activity relationships (SARs) developed from our previous efforts on a number of related bicyclic series yielded compound 2s (BMS-767778) with an overall activity, selectivity, efficacy, PK, and developability profile suitable for progression into the clinic. SAR in the series and characterization of 2s are described.
