915762-97-9Relevant articles and documents
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein i (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides
Moore, William J.,Kern, Jeffrey C.,Bhat, Ramesh,Commons, Thomas J.,Fukayama, Shoichi,Goljer, Igor,Krishnamurthy, Girija,Magolda, Ronald L.,Nogle, Lisa,Pitts, Keith,Stauffer, Barb,Trybulski, Eugene J.,Welmaker, Gregory S.,Wilson, Matthew,Bodine, Peter V. N.
experimental part, p. 105 - 116 (2009/08/07)
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic a