915949-00-7

Basic information

• Product Name: 5-chloro-N,N-dimethylpyrazine-2-carboxamide
• Synonyms: 5-chloro-N,N-dimethylpyrazine-2-carboxamide
• CAS NO: 915949-00-7
• Molecular Weight: 185.613
• Mol File: 915949-00-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 5-chloro-N,N-dimethylpyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-N,N-dimethylpyrazine-2-carboxamide(915949-00-7)
• EPA Substance Registry System: 5-chloro-N,N-dimethylpyrazine-2-carboxamide(915949-00-7)

Safety Data

• Hazardous Substances Data: 915949-00-7(Hazardous Substances Data)

Upstream product

• 36070-80-1 5-chloropyrazinoic acid 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 
• 88625-23-4 5-chloropyrazine-2-carbonyl chloride 

Downstream Products

• 1020668-74-9 methyl 3-[5-(dimethylcarbamoyl)pyrazin-2-yl]oxy-5-hydroxy-benzoate 
• 1020668-62-5 5-[3-[(2S)-1-(difluoromethoxy)propan-2-yl]oxy-5-[(1-methylpyrazol-3-yl)carbamoyl]phenoxy]-N,N-dimethyl-pyrazine-2-carboxamide 
• 1020668-68-1 methyl 5-[(2S)-1-(difluoromethoxy)propan-2-yl]oxy-3-[5-(dimethylcarbamoyl)pyrazin-2-yl]oxy-benzoate 
• 1020668-71-6 methyl 3-[5-(dimethylcarbamoyl)pyrazin-2-yl]oxy-5-[(2S)-1-tripropan-2-ylsilyloxypropan-2-yl]oxy-benzoate 
• 1020668-59-0 5-[3-[(2S)-1-(difluoromethoxy)propan-2-yl]oxy-5-[(5-methylpyrazin-2-yl)carbamoyl]phenoxy]-N,N-dimethyl-pyrazine-2-carboxamide 
• 1352570-06-9 N,N-dimethyl-5-(3-(1-methyl-2-oxopyrrolidin-3-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-yl)phenoxy)pyrazine-2-carboxamide 
• 1352571-64-2 C₂₈H₂₉N₅O₅ 
• 1352570-13-8 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide 
• 1352571-67-5 C₂₈H₂₉N₅O₆ 
• 1352570-02-5 (S)-5-(3-(1-hydroxypropan-2-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide 
• 1020855-39-3 methyl 3-[5-(dimethylcarbamoyl)pyrazin-2-yl]oxy-5-[(3S)-1-methyl-2-oxo-pyrrolidin-3-yl]oxy-benzoate 
• 915949-01-8 methyl 3-[5-(dimethylcarbamoyl)pyrazin-2-yl]oxy-5-[(2S)-1-methoxypropan-2-yl]oxy-benzoate 

Relevant articles and documents

SUBSTITUTED N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE OR N-(METHYL-D3)-NICOTINAMIDE COMPOUNDS AS IL-12, IL-23 AND/OR IFNALPHA MODULATORS

There are disclosed compounds of the following formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating inflammatory and autoimmune diseases or disorders.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES

Compounds having the following formula (I), or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.