916176-50-6

Basic information

• Product Name: 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER
• Synonyms: 1-[(4-METHYLPHENYL)SULFONYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRROLO[2,3-B]PYRIDINE;1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER;1-PHENYLSULFONYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRROLO[2,3-B]PYRIDINE;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 1-[(4-Methylphenyl)sulfonyl]-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-[(4-Methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyr;1-[(4-Methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b];1-(4-methylphenyl)sulfonyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine
• CAS NO: 916176-50-6
• Molecular Formula: C₂₀H₂₃BN₂O₄S
• Molecular Weight: 398.28
• Mol File: 916176-50-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 572.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.22±0.30(Predicted)
• CAS DataBase Reference: 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER(916176-50-6)
• EPA Substance Registry System: 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER(916176-50-6)

Safety Data

• Hazardous Substances Data: 916176-50-6(Hazardous Substances Data)

Usage

General Description

1-Tosyl-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester is a chemical compound with the formula C20H23BFNO4S. It is commonly used as a reagent in organic synthesis and medicinal chemistry. 1-TOSYL-1H-PYRROLO[2,3-B]PYRIDINE-4-BORONIC ACID PINACOL ESTER is a boronic acid ester, which is a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and materials. The tosyl group provides stability and protection to the boronic acid functionality, making it a useful intermediate in the synthesis of various biologically active compounds. Its unique structure and properties make it a valuable tool for researchers and chemists working in the field of drug discovery and development.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 348640-06-2 4-bromo-7-azaindole 
• 271-63-6 7-Azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 348640-07-3 4-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 916176-59-5 4-(6-fluoropyridin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 1352226-88-0 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine 
• 1352226-87-9 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine 
• 1352232-88-2 (3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine 
• 1352227-13-4 (R)-3-methyl-4-(6-((R)-S-methylsulfonimidoylmethyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine 
• 1352232-89-3 (3R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine 
• 1394070-94-0 5-(4-(methylsulfonyl)benzyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one 
• 945865-15-6 4-[1-Ethyl-3-(3-nitrophenyl)-1H-pyrazol-4-yl]-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 
• 916176-67-5 2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile 

Relevant articles and documents

Pyrimidine derivative, and preparation method and application thereof

The invention discloses a compound represented by general formula (I) capable of being used as an ATR protein kinase inhibitor, and an isomer or pharmaceutically acceptable salt thereof. The compound, and the isomer or the pharmaceutically acceptable salt thereof can be used for preparing medicines for treating and/or preventing hyperproliferative diseases.

HETEROCYCLIC INHIBITORS OF ATR KINASE

The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

SUBSTITUTED INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS

The present invention provides substituted indazole compound of formula (I) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK4 and/or for the treatment of diseases or disorders induced by IRAK4.