916420-30-9 Usage
Description
6-Bromo-4-chloropyrrolo[1,2-f][1,2,4]triazine is a heterocyclic compound characterized by the presence of a pyrrolo[1,2-f][1,2,4]triazine ring system with a bromo and chloro substituent at the 6th and 4th positions, respectively. This unique molecular structure endows it with potential applications in various fields, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
6-Bromo-4-chloropyrrolo[1,2-f][1,2,4]triazine is used as a key intermediate in the synthesis of condensed pyridazine or pyrimidine derivatives, which are known as Bruton's tyrosine kinase (BTK) inhibitors. BTK inhibitors are a class of drugs that target the BTK enzyme, playing a crucial role in the regulation of B-cell activation, proliferation, and survival. These inhibitors have shown promise in the treatment of various B-cell malignancies, such as chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), and autoimmune diseases.
In the preparation of BTK inhibitors, 6-bromo-4-chloropyrrolo[1,2-f][1,2,4]triazine serves as a valuable building block, allowing for the development of novel and more effective therapeutic agents. Its unique structural features enable the design of compounds with improved potency, selectivity, and pharmacokinetic properties, ultimately leading to better treatment outcomes for patients suffering from B-cell related disorders and autoimmune conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 916420-30-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,6,4,2 and 0 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 916420-30:
(8*9)+(7*1)+(6*6)+(5*4)+(4*2)+(3*0)+(2*3)+(1*0)=149
149 % 10 = 9
So 916420-30-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrClN3/c7-4-1-5-6(8)9-3-10-11(5)2-4/h1-3H
916420-30-9Relevant articles and documents
DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS
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Paragraph 000562, (2019/11/04)
The invention provides dihydroisoquinoline-2(1H)-carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting HPK1 activity.